Preclinical and clinical strategies for development of telomerase and telomere inhibitors.
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Summary
The current relevant biology of the enzyme, the challenges encountered in the preclinical phase of target development and the current efforts that focus on telomeres and telomerase as therapeutic targets are reviewed.
- Type
- review
- Published
- 1997-11-01
- Cited by
- 61
- References
- 110
- OpenAlex
- https://openalex.org/W1948149561
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40546588
Keywords
Telomere, Telomerase, Medicine, Cancer research, Computational biology
References
- Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.
- Telomerase activity is induced by the stimulation to antigen receptor in human peripheral lymphocytes.
- Telomerase activity in normal human epithelial cells.
- Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids.
- A novel quantitative 'stretch PCR assay', that detects a dramatic increase in telomerase activity during the progression of myeloid leukemias.
- Telomerase activity in human renal cell carcinoma.
- Telomerase activity in normal leukocytes and in hematologic malignancies.
- Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines.
- A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon.
- Activation of telomerase in human lymphocytes and hematopoietic progenitor cells.
- Telomerase activity: a prevalent marker of malignant human prostate tissue.
- Telomerase activity in human bladder cancer.
- Telomere shortening in renal cell carcinoma.
- Telomere elongation in immortal human cells without detectable telomerase activity.
- Telomere shortening associated with disease evolution patterns in myelodysplastic syndromes.
- Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions.
- Telomere dynamics in an immortal human cell line.
- Telomerase activity in oral leukoplakia and head and neck squamous cell carcinoma.
- Telomerase activity is detected in pancreatic cancer but not in benign tumors.
- Oligonucleotides complementary to the Oxytricha nova telomerase RNA delineate the template domain and uncover a novel mode of primer utilization
Cited by
- DNA G-Quadruplexes, Telomere-Specific Proteins and Telomere-Associated Enzymes as Potential Targets for New Anticancer Drugs
- Telomerase inhibition by peptide nucleic acids reverses `immortality' of transformed human cells
- Renal cell carcinoma (RCC) and telomerase activity: relationship to stage.
- In situ analysis of telomerase RNA gene expression as a marker for tumor progression.
- Telomeres and telomerase : methods and protocols
- BIRC7- and RTEL1-knockdown in the human colorectal cancer cell line HT29 with chromosomal 20q amplification : effects on cell proliferation and cell death
- Targeting telomeres and telomerase.
- Detection of telomerase inhibitors based on g-quadruplex ligands by a modified telomeric repeat amplification protocol assay.
- DNA relaxation and cleavage assays to study topoisomerase I inhibitors.
- Telomerase and oral cancer.
- Energetics of quadruplex-drug recognition in anticancer therapy.
- Achievements and future of chemotherapy.
- Development of telomerase inhibitors
- G-quadruplex DNA: a potential target for anti-cancer drug design.
- Telomerase - strategies to exploit an important chemotherapeutic target
- 9‐Hydroxyellipticine inhibits telomerase activity in human pancreatic cancer cells
- In vitro and in vivo treatment of colon cancer by VIP antagonists.
- Malignant changes in the prostate with ageing.
- Influence of telomerase activity on bone and soft tissue tumors
- Dimethyl sulfoxide (DMSO) causes a reversible inhibition of telomerase activity in a Burkitt lymphoma cell line.
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- Telomerase inhibition alters telomere maintenance mechanisms in laryngeal squamous carcinoma cells