A Protein-Counting Mechanism for Telomere Length Regulation in Yeast
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Summary
In the yeast Saccharomyces cerevisiae, telomere elongation is negatively regulated by the telomeres repeat-binding protein Rap1p, such that a narrow length distribution of telomerre repeat tracts is observed.
- Type
- article
- Published
- 1997-02-14
- Cited by
- 525
- References
- 32
- OpenAlex
- https://openalex.org/W1978002329
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10222145
Keywords
Telomere, Telomere-binding protein, Saccharomyces cerevisiae, Biology, DNA
References
- Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae.
- C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae
- Genetic control of chromosome length in yeast.
- The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human.
- Saccharomyces telomeres assume a non-nucleosomal chromatin structure.
- RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability.
- TLC1: template RNA component of Saccharomyces cerevisiae telomerase.
- The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo.
- Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein.
- Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance
- Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast.
- Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.
- RAP1 stimulates single- to double-strand association of yeast telomeric DNA: implications for telomere-telomere interactions.
- Spreading of transcriptional represser SIR3 from telomeric heterochromatin
- Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites.
- SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.
- Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast
- A Human Telomeric Protein
- Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription.
- The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing
Cited by
- DNA G-Quadruplexes, Telomere-Specific Proteins and Telomere-Associated Enzymes as Potential Targets for New Anticancer Drugs
- In Vitro Properties of the Conserved Mammalian Protein hnRNP D Suggest a Role in Telomere Maintenance
- Analysis of the RAP1 protein binding to homogeneous telomeric repeats in Saccharomyces castellii
- Rap1 affects the length and heterogeneity of human telomeres.
- Limited TTP supply affects telomere length regulation in a telomerase-independent fashion
- Telomeres and telomerase: from basic research to clinical applications.
- Epigenetics in Saccharomyces cerevisiae.
- Endogenous Hot Spots of De Novo Telomere Addition in the Yeast Genome Contain Proximal Enhancers That Bind Cdc13
- The role of the Ku complex in protecting a novel telomere end structure
- Exploring the assembly and function of the telomerase accessory proteins Est1 and Est3 in Saccharomyces cerevisiae
- Distinct Functions of POT1 in Telomere Protection and Length Regulation
- RNA and protein interactions modulated by protein arginine methylation.
- Telomere structural dynamics in genome integrity control and carcinogenesis.
- Examining the regulation of DNA end-processing at telomeres and double-strand breaks
- Functional Analysis of CDC13 Regulation in Budding Yeast
- Cell cycle-dependent modification of Pot1 and its effects on telomere function
- Silencing, Heterochromatin and DNA Double Strand Break Repair
- The Molecular Interfaces of Telomerase and Telomere Proteins in Yeast and Humans
- Analysis of the recruitment of telomeric factors to a DNA double strand break in "Saccharomyces cerevisiae"
- Plant Cytogenetics
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- POT1 as a terminal transducer of TRF1 telomere length control
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