Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal
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Summary
The results of biophysical experiments in solution and computational studies that are inconsistent with the reported crystal structure suggest that the biologically relevant structure of the human telomere quadruplex in K+ solution is not the one determined in the published crystalline state.
- Type
- article
- Published
- 2005-08-16
- Cited by
- 319
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W2165153689
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15295771
Keywords
Telomere, Biology, G-quadruplex, Genetics, Crystal (programming language)
References
- Crystal structure of four-stranded Oxytricha telomeric DNA
- DNA G-Quadruplexes, Telomere-Specific Proteins and Telomere-Associated Enzymes as Potential Targets for New Anticancer Drugs
- Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions.
- Fluorescence studies of nucleotides and polynucleotides. I. Formycin, 2-aminopurine riboside, 2,6-diaminopurine riboside, and their derivatives.
- Structure and stability of human telomeric sequence.
- Covalent ligation studies on the human telomere quadruplex
- The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer.
- Fluorescence properties of 2-aminopurine in human telomeric DNA.
- Chemical approaches to the discovery and development of cancer therapies
- Excitation energy transfer in DNA: duplex melting and transfer from normal bases to 2-aminopurine.
- G‐quadruplexes as therapeutic targets
- Determinants of DNA quadruplex structural type: sequence and potassium binding.
- DNA and its associated processes as targets for cancer therapy
- G-quadruplex DNA: a potential target for anti-cancer drug design.
- Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer
- Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
- Refined solution structure of the dimeric quadruplex formed from the Oxytricha telomeric oligonucleotide d(GGGGTTTTGGGG).
- An ambiguous structure of a DNA 15-mer thrombin complex.
- Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systems.
- G-quadruplexes as targets for drug design.
Cited by
- Noncanonical structures and their thermodynamics of DNA and RNA under molecular crowding: beyond the Watson-Crick double helix.
- Processing of Alternative DNA Structures in the Human Telomere
- In-cell optical imaging of exogenous G-quadruplex DNA by fluorogenic ligands
- Interactions between platinum--intercalator hybrid agents and the human telomeric G-quadruplex
- Molecular crowding and hydration regulating of G-quadruplex formation.
- Energetics of ligand binding to G-quadruplexes.
- G-quadruplexes: from guanine gels to chemotherapeutics.
- Selective Recognition of Quadruplex DNA by Small Molecules
- hAGT inhibitors as chemotherapy enhancers
- Utilisation de gabarits peptidiques pour le contrôle de l'auto-assemblage de dérivés de la Guanine : Des tétrades de guanines aux quadruplexes d'acides nucléiques.
- Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad
- Investigation of quadruplex structure under physiological conditions using in-cell NMR.
- Overview of Formation of G‐Quadruplex Structures
- Sedimentation Velocity Ultracentrifugation Analysis for Hydrodynamic Characterization of G-Quadruplex Structures
- Human telomeric G‐quadruplex: structures of DNA and RNA sequences
- Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models
- Stability of human telomere quadruplexes at high DNA concentrations.
- Discovery and Identification of New DNA Photoproducts and Investigation of the Redox Mechanism of Human Apurinic/Apyrimidinic Endonuclease 1 (hApe1) Protein
- The Outer Limits: Telomere Maintenance by TRF2 and G-Quadruplex DNA Structures
- Human telomeric G-quadruplex: thermodynamic and kinetic studies of telomeric quadruplex stability
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- The orientation of the ends of G-quadruplex structures investigated using end-extended oligonucleotides.
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- T-loop formation by human telomeric G-quadruplex.
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