The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
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- Type
- article
- Published
- 2004-02-25
- Cited by
- 1,774
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2102891343
Keywords
AMPK, Protein kinase A, Cell biology, AMP-activated protein kinase, Kinase
References
- The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.
- Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinase.
- 5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms (*)
- Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
- Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase*
- Management of cellular energy by the AMP‐activated protein kinase system
- The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways*
- A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
- TSC2 mediates cellular energy response to control cell growth and survival.
- AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation
- LKB1, a protein kinase regulating cell proliferation and polarity
- The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
- Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis.
- Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase.
- Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
- Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
- Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex.
- Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation
- AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit.
- Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells.
Cited by
- Stimulus response coupling in the carotid body: a role for metabolic signalling
- An efficient expression system for the production of functionally active human LKB1.
- On the Characterization and Software Implementation of General Protein Lattice Models
- Dormant Pluripotent Cells Emerge during Neural Differentiation of Embryonic Stem Cells in a FoxO3-Dependent Manner
- Advances in Pattern Recognition and Image Analysis - Editorial
- LKB1 Deficient Non-small Cell Lung Cancer Cells are Vulnerable to Energy Stress Induced by ATP Depletion
- AMPK/SNF1 structure: a menage a trois of energy-sensing.
- AMP-activated protein kinase regulation of myeloid antigen presenting cell activity.
- INHIBITION OF CHOLESTEROL SYNTHESIS BY POLICOSANOL
- The Effects of GMS Immunity-Related GTPases on Guanylate-Binding Proteins, Protein Aggregate Formation, and Macroautophagy
- Insights into the regulation of tumor dormancy by angiogenesis in experimental tumors.
- Tuberous sclerosis complex and DNA repair.
- Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations.
- Natural-agent mechanisms and early-phase clinical development.
- Translational control of chronic pain.
- Cell cycle regulation by the nutrient-sensing mammalian target of rapamycin (mTOR) pathway.
- Novel Posttranslational Modification in LKB1 Activation and Function
- Adrenergic signaling in insulin-sensitive tissues
- 真核細胞のエネルギー・センサー「AMPキナーゼ」
- Sphingolipids Are Required for Efficient Triacylglycerol Loss in Conjugated Linoleic Acid Treated Adipocytes
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