Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
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Summary
It is shown that leptin selectively stimulates phosphorylation and activation of the α2 catalytic subunit of AMPK (α2 AMPK) in skeletal muscle, thus establishing a previously unknown signalling pathway for leptin, and identifying AMPK as a principal mediator of the effects of leptin on fatty-acid metabolism in muscle.
- Type
- article
- Published
- 2002-01-17
- Cited by
- 2,110
- References
- 38
- OpenAlex
- https://openalex.org/W2042444876
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4409274
Keywords
Leptin, Chemistry, Protein kinase A, Beta oxidation, AMP-activated protein kinase
References
- Malonyl-CoA, fuel sensing, and insulin resistance.
- Central nervous system control of food intake
- Acute stimulation of glucose metabolism in mice by leptin treatment
- Evolution and transmission of stable CTL escape mutations in HIV infection
- Leptin and the regulation of body weight in mammals
- Definition of an epitope and MHC class I molecule recognized by gag-specific cytotoxic T lymphocytes in SIVmac-infected rhesus monkeys.
- Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle*
- Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef
- Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse.
- The regulation of AMP-activated protein kinase by phosphorylation.
- Adaptive Evolution of Human Immunodeficiency Virus-Type 1 During the Natural Course of Infection
- Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
- Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2
- Regulation of fatty acid homeostasis in cells: novel role of leptin.
- Dual regulation of the AMP‐activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle
- Receptor-mediated regional sympathetic nerve activation by leptin.
- Phenotypic Analysis of Antigen-Specific T Lymphocytes
- Sodium pump in skeletal muscle: central nervous system-induced suppression by alpha-adrenoreceptors.
- Analysis of Gag-specific Cytotoxic T Lymphocytes in Simian Immunodeficiency Virus–infected Rhesus Monkeys by Cell Staining with a Tetrameric Major Histocompatibility Complex Class I–Peptide Complex
- Characterization of Primary Isolate-Like Variants of Simian-Human Immunodeficiency Virus
Cited by
- Crosstalk Between Apoptosis and Autophagy : BH3 Mimetics Activate Multiple Pro-Autophagic Pathways
- Coordinate Regulation of Malonyl-CoA Decarboxylase,sn-Glycerol-3-phosphate Acyltransferase, and Acetyl-CoA Carboxylase by AMP-activated Protein Kinase in Rat Tissues in Response to Exercise*
- Activation of 5′-AMP-activated Kinase Is Mediated through c-Src and Phosphoinositide 3-Kinase Activity during Hypoxia-Reoxygenation of Bovine Aortic Endothelial Cells
- Integrative physiology of human adipose tissue
- The AMP-activated protein kinase cascade--a unifying system for energy control.
- Regulation of Fasted Blood Glucose by Resistin
- Cardiovascular implications of HIV-associated dyslipidemic lipodystrophy
- The role of stearoyl-CoA desaturase in the control of metabolism.
- Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.
- Intraperitoneal leptin regulates lipid metabolism in ethanol supplemented Mus musculas heart.
- Non‐invasive markers to predict the liver fibrosis in non‐alcoholic fatty liver disease
- AMP-activated protein kinase--the fat controller of the energy railroad.
- The metabolic syndrome: role of skeletal muscle metabolism.
- Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults.
- [Effects of leptin on porcine primary adiocytes lipolysis and mRNA expression of key lipolytic enzymes].
- Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep.
- Leptin gene transfer regulates fibromuscular development and lipid deposition in muscles via SIRT1, FOXO3a and PGC-1α in mice in vivo.
- Update on adipose tissue blood flow regulation.
- Decoding Insulin Resistance and Metabolic Syndrome for Promising Therapeutic Intervention
- Effects of 6‐meals‐a‐day feeding and 6‐meals‐a‐day feeding combined with adrenalectomy on daily gene expression rhythms in rat epididymal white adipose tissue
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