Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinase.

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Summary

Results indicate that AICAR is a powerful inhibitor of glucocorticoid-induced apoptosis and suggest that AMPK activation may interfere with a step in the apoptotic cascade triggered by dexamethasone.

Type
article
Published
1998-02-24
Cited by
85
References
29

Keywords

Ribonucleoside, Activator (genetics), Glucocorticoid, Protein kinase A, Chemistry

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