Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinase.
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Summary
Results indicate that AICAR is a powerful inhibitor of glucocorticoid-induced apoptosis and suggest that AMPK activation may interfere with a step in the apoptotic cascade triggered by dexamethasone.
- Type
- article
- Published
- 1998-02-24
- Cited by
- 85
- References
- 29
- OpenAlex
- https://openalex.org/W1972877540
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19295418
Keywords
Ribonucleoside, Activator (genetics), Glucocorticoid, Protein kinase A, Chemistry
References
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- Glucocorticoid‐induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor.
- Apoptosis: mode of cell death induced in T cell leukemia lines by dexamethasone and other agents
- Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism.
- The biochemistry of programmed cell death
- The role of proteases during apoptosis
- 5-Amino-4-imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells.
- The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion.
- Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinase
- ATP depletion inhibits glucocorticoid-induced thymocyte apoptosis.
- Inhibition of the expression of ornithine decarboxylase and c-Myc by cell-permeant ceramide in difluoromethylornithine-resistant leukaemia cells.
- Bcl-2 relieves the trans-repressive function of the glucocorticoid receptor and inhibits the activation of CPP32-like cysteine proteases.
- Identification of Raf‐1 Ser621 kinase activity from NIH 3T3 cells as AMP‐activated protein kinase
- Aminoimidazole carboxamide ribonucleoside toxicity: A model for study of pyrimidine starvation
- Control of hepatic fatty acid oxidation by 5'-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism.
- Involvement of cellular proteolytic machinery in apoptosis.
- Characterisation of 5'-AMP-activated protein kinase in human liver using specific peptide substrates and the effects of 5'-AMP analogues on enzyme activity.
- 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
- Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis
Cited by
- Investigation of the intrinsic mechanism of drug resistance in multiple myeloma
- The in vitro antiapoptotic effect of dehydroepiandrosterone sulfate in mouse thymocytes and its relation to caspase-3/caspase-6
- IMPLEMENTATION AND ASSESSMENT OF HYPERGLYCEMIC CONDITIONS FOR THE CREATION OF A DIABETIC BLOOD VESSEL MIMIC
- Multiple Mechanisms Mediating the Starvation Induced Activation of Recombination at HIS4 in Saccharomyces Cerevisiae
- Attenuation of macrophage apoptosis by the cAMP-signalling system
- AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
- The AMPK enzyme-complex: from the regulation of cellular energy homeostasis to a possible new molecular target in the management of chronic inflammatory disorders
- 5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells.
- The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells.
- 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
- Dealing with energy demand: the AMP-activated protein kinase.
- Fuel feeds function: energy metabolism and the T-cell response
- AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside.
- 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages.
- The AMP‐activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes
- Recent insights into the mechanism of glucocorticosteroid-induced apoptosis
- Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis.
- AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
- AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation
- Sustained activation of AMP‐activated protein kinase induces c‐Jun N‐terminal kinase activation and apoptosis in liver cells
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