Long non-coding RNAs: definitions, functions, challenges and recommendations
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Summary
The definition and nomenclature of lncRNAs and their conservation, expression, phenotypic visibility, structure and functions are addressed, and a shared viewpoint on their features and functions is provided.
- Type
- review
- Published
- 2023-01-03
- Cited by
- 1,885
- References
- 469
- Access
- Open access
- OpenAlex
- https://openalex.org/W4313488537
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:255456200
Keywords
Computational biology, Coding (social sciences), Long non-coding RNA, Computer science, Biology
References
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- Yeast telomerase RNA: a flexible scaffold for protein subunits.
- Deconstructing the Dogma
- A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
- MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
- A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains
- DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer.
- Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice.
- Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1
- Stable CoT-1 repeat RNA is abundant and associated with euchromatic interphase chromosomes
- The accessible chromatin landscape of the human genome
Cited by
- Conformation and structural dynamics of the Xist lncRNA A-repeats
- Effect of Single Nucleotide Polymorphisms on the structure of long noncoding RNAs and their interaction with RNA Binding Proteins
- Self-empowerment of life through RNA networks, cells and viruses
- Differential expression patterns of long noncoding RNAs in a pleiomorphic diatom and relation to hyposalinity
- Evidence for Existence of Multiple Functional Human Small RNAs Derived from Transcripts of Protein-Coding Genes
- Long Non-Coding RNAs of Plants in Response to Abiotic Stresses and Their Regulating Roles in Promoting Environmental Adaption
- The landscape of human p53‐regulated long non‐coding RNAs reveals critical host gene co‐regulation
- Long noncoding RNA AL109754.1 Regulates Myeloid Dendritic Cell Differentiation and Potentiates TLR signaling
- LINC00261 expression reduces mutation accumulation while conferring resistance to cisplatin and altering the tumor-immune microenvironment in lung adenocarcinoma
- Specificity Proteins (Sp) and Cancer
- Population-level annotation of lncRNA transcription in Arabidopsis reveals extensive variation associated with transposable element-like silencing
- Long noncoding RNAs in cardiovascular disease
- Genetics and Epigenetics: Implications for the Life Course of Gestational Diabetes
- Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma
- Genetic cold cases: lessons from solving complex congenital limb disorders
- The status of the human gene catalogue
- PITAR, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA
- LncRNA EPR regulates intestinal mucus production and protects against inflammation and tumorigenesis
- Peroxisome Proliferator-Activated Receptor-γ as a Target and Regulator of Epigenetic Mechanisms in Nonalcoholic Fatty Liver Disease
- mRNA and lncRNA co-expression network in mice of acute intracerebral hemorrhage
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