MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
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Summary
It is shown that MEG3 and EZH2 share common target genes, including the TGF-β pathway genes, and that RNA–DNA triplex formation could be a general characteristic of target gene recognition by the chromatin-interacting lncRNAs.
- Type
- article
- Published
- 2015-07-24
- Cited by
- 638
- References
- 71
- Access
- Open access
- OpenAlex
- https://openalex.org/W1793796070
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5891356
Keywords
RNA, Long non-coding RNA, DNA, Non-coding RNA, Gene
References
- The Xist lncRNA exploits three-dimensional genome architecture to spread across the X-chromosome
- Triple helix formation by oligopurine-oligopyrimidine DNA fragments. Electrophoretic and thermodynamic behavior.
- Physicochemical Studies of the d(G3T4G3)*d(G3A4G3)•d(C3T4C3) Triple Helix (*)
- Mitochondrial DNA structure and expression in specialized subtypes of mammalian striated muscle
- High-resolution Xist binding maps reveal 2-step spreading during X-inactivation
- The non-coding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting Mll1 to chromatin
- The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex
- A vertebrate Polycomb response element governs segmentation of the posterior hindbrain.
- Long noncoding RNAs regulate adipogenesis
- Polycomb proteins targeted by a short repeat RNA to the mouse X-chromosome
- GREAT improves functional interpretation of cis-regulatory regions
- Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions
- Structure of a Polycomb Response Element and In Vitro Binding of Polycomb Group Complexes Containing GAGA Factor
- Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis.
- The TGF-β/Smad pathway induces breast cancer cell invasion through the up-regulation of matrix metalloproteinase 2 and 9 in a spheroid invasion model system
- Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2
- The genomic binding sites of a noncoding RNA
- Control of somatic tissue differentiation by the long non-coding RNA TINCR
- Arabidopsis Polycomb Repressive Complex 2 binding sites contain putative GAGA factor binding motifs within coding regions of genes
- Antibodies recognise specific structures of triple-helical polynucleotides built on poly(A) or poly(dA)
Cited by
- EZH2 protein expression in normal breast epithelium and risk of breast cancer: results from the Nurses’ Health Studies
- Identification of long non-coding RNA-related and –coexpressed mRNA biomarkers for hepatocellular carcinoma
- Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells
- Crosstalk between transforming growth factor-β signaling pathway and long non-coding RNAs in cancer.
- Triplex Domain Finder: Detection of Triple Helix Binding Domains in Long Non-Coding RNAs
- LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure.
- Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163
- Non-Coding RNA: Sequence-Specific Guide for Chromatin Modification and DNA Damage Signaling
- Tenogenic differentiation of mesenchymal stem cells and noncoding RNA: From bench to bedside.
- Non-coding RNAs as modulators of the cardiac fibroblast phenotype.
- Long noncoding RNA-MEG3 is involved in diabetes mellitus-related microvascular dysfunction.
- Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin
- Characters, functions and clinical perspectives of long non-coding RNAs
- Noncoding RNAs in Tumor Epithelial-to-Mesenchymal Transition
- Long noncoding RNAs in regulation of human breast cancer.
- From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis
- An overview of long non-coding RNAs in ovarian cancers
- The non-coding RNA composition of the mitotic chromosome by 5′-tag sequencing
- Mechanisms of long noncoding RNA function in development and disease
- Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort
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