Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019.
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Summary
Although combinatorial chemistry techniques have succeeded as methods of optimizing structures and have been used very successfully in the optimization of many recently approved agents, they are still able to identify only two de novo combinatorials compounds approved as drugs in this 39-year time frame.
- Type
- review
- Published
- 2020-03-12
- Cited by
- 5,795
- References
- 87
- Access
- Open access
- OpenAlex
- https://openalex.org/W3011366455
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:212679186
Keywords
Biosimilar, Natural product, Natural (archaeology), Product (mathematics), Medicine
References
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- Biosynthetic medicinal chemistry of natural product drugs
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- Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression
- Resistance-Gene Directed Discovery of a Natural Product Herbicide with a New Mode of Action
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- Identification of Natural Compounds against Neurodegenerative Diseases Using In Silico Techniques
- Detection of Adulteration in Hydrastis canadensis (Goldenseal) Dietary Supplements via Untargeted Mass Spectrometry-based Metabolomics
- Engineering Salinispora tropica for heterologous expression of natural product biosynthetic gene clusters
- Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels
- Natural Products from Anaerobes
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