Natural product-like chemical space: search for chemical dissectors of macromolecular interactions.
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Summary
The emerging area of diversity-oriented synthesis (DOS) is beginning to provide natural product-like chemical probes that may be useful in this arena, and these probes may be rich in stereochemical and three-dimensional structural diversity.
- Type
- review
- Published
- 2005-06-01
- Cited by
- 78
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W1981751808
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12200625
Keywords
Chemical space, Chemical biology, Natural product, Macromolecule, Function (biology)
References
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Cited by
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- Exploring a "Nature-Inspired" Strategy for Enhancing the Pharmacology of Small Molecules: Towards the Development of Next Generation Anti-Infectives.
- Selected hybrid natural products as tubulin modulators.
- Stereoselective Synthesis of Tricyclic Diproline Analogues that Mimic a PPII Helix: Structural Consequences of Ring-Size Variation
- A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay
- An Intramolecular Heck Approach To Obtain 17-Membered Macrocyclic Diversity and the Identification of an Antiangiogenesis Agent from a Zebrafish Assay
- Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.
- Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries.
- Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of benzothiazoles.
- Challenges and Perspectives of Chemical Biology, a Successful Multidisciplinary Field of Natural Sciences
- Natural Products as Sources of New Drugs over the 30 Years from 1981 to 2010
- Natural product diversity and its role in chemical biology and drug discovery
- Stereoselective synthesis of a novel natural carbasugar and analogues from hydroxymethylated cycloalkenone scaffolds
- Towards the optimal screening collection: a synthesis strategy.
- Peptide scalpels for site-specific dissection of the DNA-protein interface.
- Solid-Phase Synthesis of [5.5]-Spiroketals
- Chemical intervention in signalling networks: recent advances and applications†
- Skeletal Diversity via Cationic Rearrangements of Substituted Dihydropyrans
- Stereocomplementary synthesis of a natural product-derived compound collection on a solid phase.
- Chemoenzymatic synthesis and resolution of compounds containing a quaternary stereocenters adjacent to a carbonyl group
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