On the Mechanism of Action of Dragmacidins I and J, Two New Representatives of a New Class of Protein Phosphatase 1 and 2A Inhibitors
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Summary
Two new brominated bis(indole) alkaloids, dragmacidins I and J, showing low micromolar cytostatic activity, along with three known congeners were isolated from the Tanzanian sponge Dragmacidon sp.
- Type
- article
- Published
- 2018-04-03
- Cited by
- 17
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W2795919172
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:49863728
Keywords
Phosphatase, Protein phosphatase 2, Mechanism of action, Mode of action, Stereochemistry
References
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- Small-molecule library screening by docking with PyRx.
- Molecular symmetry: a structural property frequently present in new cytotoxic and proapoptotic drugs.
- A combination of docking, QM/MM methods, and MD simulation for binding affinity estimation of metalloprotein ligands.
- Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1.
- 19-epi-okadaic acid, a novel protein phosphatase inhibitor with enhanced selectivity.
- Dragmacidin, a new cytotoxic bis(indole) alkaloid from a deep water marine sponge, Dragmacidon sp
- Marine sponge bis(indole) alkaloids that displace ligand binding to α1 adrenergic receptors
- Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies
- Dragmacidins: new protein phosphatase inhibitors from a southern australian deep-water marine sponge, spongosorites sp
- Antimicrobial activity and cytotoxicity of bis(indole) alkaloids from the sponge Spongosorites sp.
- Crystal Structure of the Tumor-promoter Okadaic Acid Bound to Protein Phosphatase-1*
- Corozalic acid: a key okadaic acid biosynthetic precursor with phosphatase inhibition activity.
- 6-BROMOTRYPTAMINE DERIVATIVES FROM THE GULF OF CALIFORNIA TUNICATE DIDEMNUM CANDIDUM
- Asymmetric aminohydroxylation of vinyl indoles: a short enantioselective synthesis of the bisindole alkaloids dihydrohamacanthin A and dragmacidin A
- Brominated bis(indole) alkaloids from the marine sponge Hexadella sp.
- A new bis-(indole) alkaloid from a deep-water marine sponge of the genus Spongosorites
- Bisindole alkaloids of the topsentin and hamacanthin classes from a marine sponge Spongosorites sp.
- Belizeanic acid: a potent protein phosphatase 1 inhibitor belonging to the okadaic acid class, with an unusual skeleton.
- A total synthesis of dragmacidin B
Cited by
- Computational Methodologies in the Exploration of Marine Natural Product Leads
- Structural and Bioactive Studies of Halogenated Constituents from Sponges.
- Community composition and functional prediction of prokaryotes associated with sympatric sponge species of southwestern Atlantic coast
- Marine Indole Alkaloids—Isolation, Structure and Bioactivities
- Marine-Derived Indole Alkaloids and Their Biological and Pharmacological Activities
- Marine natural products.
- Biomaterials and Bioactive Natural Products from Marine Invertebrates: From Basic Research to Innovative Applications
- Review Marine Pharmacology in 2018: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action.
- Pleiotropy of PP2A Phosphatases in Cancer with a Focus on Glioblastoma IDH Wildtype
- Marine life as a source for breast cancer treatment: A comprehensive review.
- Marine-Derived Compounds Applied in Cardiovascular Diseases: Submerged Medicinal Industry
- The potential of marine-derived piperazine alkaloids: Sources, structures and bioactivities.
- Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development
- Studies of Chemical Distribution and Pharmacological Activities of Porifera-derived Alkaloids: A Review (2000 - 2023)
- The therapeutic potential and application of marine alkaloids in treating breast cancer
- Quantum chemical package Jaguar: A survey of recent developments and unique features.
- Recent developments in polymer chemistry, medicinal chemistry and electro-optics using Ni and Pd-based catalytic systems.
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