Next-generation characterization of the Cancer Cell Line Encyclopedia
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Summary
The original Cancer Cell Line Encyclopedia is expanded with deeper characterization of over 1,000 cell lines, including genomic, transcriptomic, and proteomic data, and integration with drug-sensitivity and gene-dependency data, which reveals potential targets for cancer drugs and associated biomarkers.
- Type
- article
- Published
- 2019-05-01
- Cited by
- 2,873
- References
- 66
- Access
- Open access
- OpenAlex
- https://openalex.org/W2944727022
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:148569379
Keywords
Computational biology, Biology, Cancer, Transcriptome, Cancer cell
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- MDM4 is a key therapeutic target in cutaneous melanoma
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- STRING v10: protein–protein interaction networks, integrated over the tree of life
- Regularization Paths for Generalized Linear Models via Coordinate Descent
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- CTC Marker CD117/c-kit Represents a Prostate Cancer Stem-Like Subpopulation Driving Progression, Migration, and TKI Resistance
- Inference of phenotype-relevant transcriptional regulatory networks elucidates cancer type-specific regulatory mechanisms in a pan-cancer study
- RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer
- Immunogenomic landscape of hematological malignancies
- A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures
- Creating reproducible pharmacogenomic analysis pipelines
- The Landscape of Cancer Cell Line Metabolism
- An integrated landscape of protein expression in human cancer
- Widespread immunogenic poly-epitope frameshift mutations in microsatellite unstable tumors
- Constitutive TRIM22 expression within the respiratory tract identifies tissue-specific and cell-type dependent intrinsic immune barriers to influenza A virus infection
- Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors
- Drug-adapted cancer cell lines as preclinical models of acquired resistance
- Studying metabolic flux adaptations in cancer through integrated experimental-computational approaches
- Molecular Treasures of Cancer Cell Lines.
- GEDS: A Gene Expression Display Server for mRNAs, miRNAs and Proteins
- H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
- BET inhibition induces an anti-apoptotic adaptive response and therapeutic vulnerability to MCL1 inhibitors in breast cancer
- Endocytic Profiling of Cancer Cell Models Reveals Critical Factors Influencing LNP-Mediated mRNA Delivery and Protein Expression.
- Diminished Condensin Gene Expression Drives Chromosome Instability That May Contribute to Colorectal Cancer Pathogenesis
- Cancer Cell Lines Are Useful Model Systems for Medical Research
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