Integrated Genomic Characterization of Papillary Thyroid Carcinoma
Explore this paper's citation graph
Summary
The genomic landscape of 496 PTCs is described and a reclassification of thyroid cancers into molecular subtypes that better reflect their underlying signaling and differentiation properties is proposed, which has the potential to improve their pathological classification and better inform the management of the disease.
- Type
- article
- Published
- 2014-10-23
- Cited by
- 2,727
- References
- 144
- Access
- Open access
- OpenAlex
- https://openalex.org/W1848939527
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6709043
Keywords
Biology, Thyroid carcinoma, Cancer research, Thyroid cancer, Gene
References
- The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
- Aumento della captazione del radioiodio indotto da selumetinib in pazienti con cancro della tiroide
- Activated ras oncogenes in human thyroid cancers.
- Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
- PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].
- Extracting Biological Meaning from Large Gene Lists with DAVID
- Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989.
- High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
- MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
- High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries
- HMGB1 induces the overexpression of miR-222 and miR-221 and increases growth and motility in papillary thyroid cancer cells.
- PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas.
- Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers"
- PathSeq: A comprehensive computational tool for the identification or discovery of microorganisms by deep sequencing of human tissue
- COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
- Statistical Significance of Clustering for High-Dimension, Low–Sample Size Data
- Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice
- PTEN Represses RNA Polymerase III-Dependent Transcription by Targeting the TFIIIB Complex
- RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
- Guided Visual Exploration of Genomic Stratifications in Cancer
Cited by
- Aberrant Expression of COT Is Related to Recurrence of Papillary Thyroid Cancer
- Thyrospheres From Normal or Malignant Thyroid Tissue Have Different Biological, Functional, and Genetic Features.
- A 3-bp Deletion VK600-1E in the BRAF Gene Detected in a Young Woman with Papillary Thyroid Carcinoma
- The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis.
- A Bedside Risk Calculator to Preoperatively Distinguish Follicular Thyroid Carcinoma from Follicular Variant of Papillary Thyroid Carcinoma
- High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor
- Multicentre validation of a microRNA-based assay for diagnosing indeterminate thyroid nodules utilising fine needle aspirate smears
- Biologic and Clinical Perspectives on Thyroid Cancer.
- A Concise Atlas of Thyroid Cancer Next-Generation Sequencing Panel ThyroSeq v.2
- Should subcentimeter non-invasive encapsulated, follicular variant of papillary thyroid carcinoma be included in the noninvasive follicular thyroid neoplasm with papillary-like nuclear features category?
- Tumor-suppressive function of UNC5D in papillary thyroid cancer
- Transcriptome Network Analysis Reveals Aging-Related Mitochondrial and Proteasomal Dysfunction and Immune Activation in Human Thyroid
- SDC4 Gene Silencing Favors Human Papillary Thyroid Carcinoma Cell Apoptosis and Inhibits Epithelial Mesenchymal Transition via Wnt/β-Catenin Pathway
- Identification of potential functional genes in papillary thyroid cancer by co-expression network analysis
- Updates in the management of thyroid nodules.
- Effects of levothyroxine therapy on bone mineral density and bone turnover markers in premenopausal women with thyroid cancer after thyroidectomy.
- Molekularpathogenese von Schilddrüsentumoren
- Thyroid Cancer: Molecular Pathogenesis, Tyrosine Kinase Inhibitors, and Other New Therapies
- Rolle der Molekularpathologie beim Schilddrüsenkarzinom
- Mouse Models of Thyroid Cancer: A 2015 Update
Related papers
- DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION
- ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ
- The experimental development and metabolism of thyroid gland tumors.
- Morphological and Histological Study on Thyroid Gland Toxicity in Male Rats Exposed to Mercury
- Studies in thyroid activity. II. The Specific Physiological Activity of Certain Constituents of the Thyroid Gland
- The Experimental Study on the Rat Thyroid Function by the Use of I131
- I(131)使用による白鼠甲状腺機能に関する実験的研究 第1編 抗甲状腺剤,甲状腺剤,甲状腺刺戟ホルモンの白鼠甲状腺に及ぼす影響
- MORPHOFUNCTIONAL CHANGES OF THE THYROID GLAND UNDER CONDITIONS OF EXPERIMENTAL HYPOTHYROID DYSFUNCTION AND PHYSICAL EXERTION
- [Long-acting thyroid stimulator (LATS) in thyroid gland diseases and its relationship to the thyroid gland antibodies].