Egg White-Derived Tripeptide IRW (Ile-Arg-Trp) Is an Activator of Angiotensin Converting Enzyme 2.
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Summary
This study established IRW as the first food-derived ACE2 activating peptide, and suggested that IRW might activate ACE2 through interaction with the subdomain I near the active site through hydrogen bonds.
- Type
- article
- Published
- 2018-10-08
- Cited by
- 43
- References
- 36
- OpenAlex
- https://openalex.org/W2896513603
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:52932024
Keywords
Renin–angiotensin system, Activator (genetics), Angiotensin II, Chemistry, Angiotensin-converting enzyme 2
References
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- Egg ovotransferrin‐derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats
- Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury.
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- Angiotensin‐Converting Enzyme Inhibitors and Insulin Sensitivity: Metabolic Effects in Hypertension, Diabetes, and Heart Failure
- ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice.
- Neuroprotective Mechanisms of the ACE2–Angiotensin-(1-7)–Mas Axis in Stroke
- Egg-Derived Tri-Peptide IRW Exerts Antihypertensive Effects in Spontaneously Hypertensive Rats
- Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury
- From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension
- Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression.
- ACE2/Ang-(1–7) signaling and vascular remodeling
- Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice
- Structure and Activity Study of Egg Protein Ovotransferrin Derived Peptides (IRW and IQW) on Endothelial Inflammatory Response and Oxidative Stress
- A new approach for identification of novel antihypertensive peptides from egg proteins by QSAR and bioinformatics
- Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease
- Casein-derived tripeptide Ile-Pro-Pro improves angiotensin-(1-7)- and bradykinin-induced rat mesenteric artery relaxation.
- ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes
Cited by
- Egg White–Derived Antihypertensive Peptide IRW (Ile‐Arg‐Trp) Reduces Blood Pressure in Spontaneously Hypertensive Rats via the ACE2/Ang (1‐7)/Mas Receptor Axis
- Identification of angiotensin converting enzyme 2 (ACE2) up-regulating peptides from pea protein hydrolysate
- Current role of in silico approaches for food enzymes
- Regulatory Effects of a Pea-Derived Peptide Leu-Arg-Trp (LRW) on Dysfunction of Rat Aortic Vascular Smooth Muscle Cells against Angiotensin II Stimulation.
- Perspectives on the Potential Benefits of Antihypertensive Peptides towards Metabolic Syndrome
- An update on ACE2 amplification and its therapeutic potential
- Food protein-derived antihypertensive peptides in the COVID-19 pandemic: friends of foes?
- The ACE2/Ang (1–7)/MasR axis as an emerging target for antihypertensive peptides
- Chicken egg white: Hatching of a new old biomaterial
- Spent Hen Protein Hydrolysate with Good Gastrointestinal Stability and Permeability in Caco-2 Cells Shows Antihypertensive Activity in SHR
- Translating bioactive peptides for COVID-19 therapy
- The Protective Effects of Tripeptides VPP and IPP against Small Extracellular Vesicles from Angiotensin II-Induced Vascular Smooth Muscle Cells Mediating Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells.
- A Novel Angiotensin Converting Enzyme 2 (ACE2) Activating Peptide: A Reflection of 10 Years of Research on a Small Peptide Ile-Arg-Trp (IRW).
- A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor
- Purification and identification of novel ACE inhibitory and ACE2 upregulating peptides from spent hen muscle proteins.
- Legumes as Functional Food for Cardiovascular Disease
- Soybean-Derived Antihypertensive Peptide LSW (Leu-Ser-Trp) Antagonizes the Damage of Angiotensin II to Vascular Endothelial Cells through the Trans-vesicular Pathway.
- Molecular Similarity Relating to a Peptide Sequence Common toAngiotensin II (ANGII) and SARS-Cov2 S-Protein
- Bioactive Peptides: From Basic Research to Clinical Trials and Commercialization.
- [20(22)E]-Lanostane Triterpenes from the Fungus Ganoderma australe
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