Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease
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Summary
ACE2 plays a crucial role in the RAS because it opposes the actions of Ang II, and current therapeutic strategies for ACE2 involve augmenting its expression using ACE2 adenovirus, recombinant ACE2 or compounds in these diseases thereby affording some organ protection.
- Type
- article
- Published
- 2012-03-20
- Cited by
- 540
- References
- 84
- Access
- Open access
- OpenAlex
- https://openalex.org/W2082133861
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16728396
Keywords
Angiotensin-converting enzyme 2, Renin–angiotensin system, Enzyme, Angiotensin II, Downregulation and upregulation
References
- Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II-Dependent Glomerulosclerosis
- ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR.
- ACE2 Activation Promotes Antithrombotic Activity
- Angiotensin-(1-7) Blockade Attenuates Captopril- or Hydralazine-Induced Cardiovascular Protection in Spontaneously Hypertensive Rats-Treated with L-NAME
- Tissue renin-angiotensin systems. Their role in cardiovascular disease.
- Renin-angiotensin system and atherothrombotic disease: from genes to treatment.
- Injections of angiotensin‐converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats
- Angiotensin‐converting enzyme 2 gene targeting studies in mice: mixed messages
- Angiotensin-converting enzyme 2 protects from severe acute lung failure
- Calmodulin interacts with angiotensin‐converting enzyme‐2 (ACE2) and inhibits shedding of its ectodomain
- Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
- Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles: Evidence for Upregulation of the Angiotensin-Converting Enzyme Homologue ACE2
- Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit.
- Expression of renin-angiotensin system components in the heart, kidneys, and lungs of rats with experimental heart failure.
- Angiotensin-Converting Enzyme 2 Overexpression in the Subfornical Organ Prevents the Angiotensin II–Mediated Pressor and Drinking Responses and Is Associated With Angiotensin II Type 1 Receptor Downregulation
- The angiotensin-converting enzyme gene family: genomics and pharmacology.
- ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice.
- The renin-angiotensin system and volume overload-induced changes in cardiac collagen and elastin.
- Effect of chronic angiotensin converting enzyme inhibition on angiotensin I and bradykinin metabolism in rats.
- A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9
Cited by
- A Genomic Survey of Angiotensin-Converting Enzymes Provides Novel Insights into Their Molecular Evolution in Vertebrates
- Association between Serum Angiotensin-converting Enzyme 2 Level with Postoperative Morbidity and Mortality after Major Pulmonary Resection in Non-small Cell Lung Cancer Patients
- Autocrine and paracrine function of Angiotensin 1-7 in tissue repair during hypertension.
- Therapeutic effect of human umbilical cord mesenchymal stem cells modified by angiotensin-converting enzyme 2 gene on bleomycin-induced lung fibrosis injury
- Angiotensin 1-7 significantly reduces diabetes-induced leukocyte recruitment both in vivo and in vitro.
- Bioactive peptides on endothelial function
- Antihypertensive Properties of a Novel Morphologic Derivative (4-tert-buthyl-2,6-bis(thiomorpholine-4-ilmethyl)phenol)
- Membrane-anchored proteases in endothelial cell biology
- Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice
- The relationship of stress and blood pressure effectors.
- Loss of angiotensin converting enzyme II (ACE2) accelerates the development of liver injury induced by thioacetamide
- Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2
- Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes
- Egg White-Derived Tripeptide IRW (Ile-Arg-Trp) Is an Activator of Angiotensin Converting Enzyme 2.
- Is the cardioprotective effect of the ACE2 activator diminazene aceturate more potent than the ACE inhibitor enalapril on acute myocardial infarction in rats?
- Effect of Prolonged Infusion of Alamandine on Cardiovascular Parameters and Cardiac ACE2 Expression in a Rat Model of Renovascular Hypertension.
- The ameliorative effect of angiotensin 1-7 on experimentally induced-preeclampsia in rats: Targeting the role of peroxisome proliferator-activated receptors gamma expression & asymmetric dimethylarginine.
- Intrarenal Renin–Angiotensin System Involvement in the Pathogenesis of Chronic Progressive Nephropathy—Bridging the Informational Gap Between Disciplines
- Decreased Renal Function Induced by High-Fat Diet in Wistar Rat: The Role of Plasma Angiotensin Converting Enzyme 2 (ACE2)
- Resveratrol ameliorates the cyclosporine-induced vascular and renal impairments: possible impact of the modulation of renin-angiotensin system.
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