Regulation of angiotensin converting enzyme II by angiotensin peptides in human cardiofibroblasts.
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Summary
It is proposed that Ang II-upregulated ACE2 may increase Ang-(1-7) formation from Ang II, and that ACE2 expression is further enhanced by Ang-(7) in a positive feedback loop.
- Type
- article
- Published
- 2010-07-01
- Cited by
- 18
- References
- 45
- OpenAlex
- https://openalex.org/W2024111867
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34426182
Keywords
Downregulation and upregulation, Angiotensin II, Renin–angiotensin system, Angiotensin-converting enzyme 2, Receptor
References
- ACE2 of the heart: From angiotensin I to angiotensin (1-7).
- Angiotensin-(1-7) Counterregulates Angiotensin II Signaling in Human Endothelial Cells
- Detection of Soluble Angiotensin-Converting Enzyme 2 in Heart Failure
- Functional angiotensin‐converting enzyme 2 is expressed in human cardiac myofibroblasts
- Interplay of angiotensin II and angiotensin(1–7) in the regulation of matrix metalloproteinases of human cardiocytes
- ACE2 gene expression is up-regulated in the human failing heart
- Counterregulatory actions of angiotensin-(1-7).
- Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme
- ACE2: a new target for cardiovascular disease therapeutics.
- Soluble Angiotensin Converting Enzyme 2 in Human Heart Failure: Relation with Myocardial Function and Clinical Outcomes
- Altered expression of FHL1, CARP, TSC-22 and P311 provide insights into complex transcriptional regulation in pacing-induced atrial fibrillation.
- A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9
- Olmesartan improves left ventricular function in pressure-overload hypertrophied rat heart by blocking angiotensin II receptor with synergic effects of upregulation of angiotensin converting enzyme 2
- Targeting the ACE2-Ang-(1–7) Pathway in Cardiac Fibroblasts to Treat Cardiac Remodeling and Heart Failure
- Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs
- Angiotensin-converting enzyme 2 is an essential regulator of heart function
- Cardiac Angiotensin-(1-7) in Ischemic Cardiomyopathy
- Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2
- Angiotensin-converting enzyme II in the heart and the kidney.
- Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart
Cited by
- Advances in the Renin Angiotensin System: Focus on Angiotensin-Converting Enzyme 2 and Angiotensin-(1–7)
- A Systematic Review to Investigate Whether Angiotensin-(1-7) Is a Promising Therapeutic Target in Human Heart Failure
- Identifying the regulatory element for human angiotensin-converting enzyme 2 (ACE2) expression in human cardiofibroblasts.
- Angiotensin II downregulates ACE2-mediated enhancement of MMP-2 activity in human cardiofibroblasts.
- Targeting the ACE2-Ang-(1–7) Pathway in Cardiac Fibroblasts to Treat Cardiac Remodeling and Heart Failure
- Effect of angiotensin II on rhythmic per2 expression in the suprachiasmatic nucleus and heart and daily rhythm of activity in Wistar rats.
- Modeling of angiotensin II-angiotensin-(1-7) counterbalance in disease progression in spontaneously hypertensive rats treated with/without perindopril.
- ACE2: Angiotensin II/Angiotensin-(1-7) balance in cardiorenal injury
- Effects of Diosgenin on Myometrial Matrix Metalloproteinase-2 and -9 Activity and Expression in Ovariectomized Rats
- The components of the angiotensin-(1-7) system are differentially expressed during follicular wave in cattle
- Angiotensin-(1-7): a new therapeutic strategy in the management of atrial fibrillation.
- ACE 2: More of Ang 1-7 or less Ang II?
- Targeting Wnt signaling to improve wound healing after myocardial infarction.
- Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications
- Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study
- The regulation of ACE-2 in the heart and lungs
- Angiotensin-(1-7) and the Heart
- angiotensin-converting enzyme 2 3.4.17.23
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