Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury.
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Summary
ACE2 is expressed in erectile tissue and its reduction is associated with hypercholesterolemia-induced ED, suggesting ACE2 as a potential target for treating ED.
- Type
- article
- Published
- 2015-02-01
- Cited by
- 24
- References
- 60
- Access
- Open access
- OpenAlex
- https://openalex.org/W1962673114
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15036998
Keywords
Angiotensin-converting enzyme 2, Endocrinology, Internal medicine, Enos, Angiotensin II
References
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- An increased arginase activity is associated with corpus cavernosum impairment induced by hypercholesterolemia.
- AVE 0991, a non‐peptide Mas‐receptor agonist, facilitates penile erection
- Telmisartan, ramipril and their combination improve endothelial function in different tissues in a murine model of cholesterol‐induced atherosclerosis
- Investigative models in erectile dysfunction: a state-of-the-art review of current animal models.
- An oral formulation of angiotensin-(1-7) reverses corpus cavernosum damages induced by hypercholesterolemia.
- Mouse Models of Atherosclerosis
- New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis
- The Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas receptor axis: A potential target for treating thrombotic diseases
- Nitric oxide: a physiologic mediator of penile erection.
- Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular cells
- Renin angiotensin system in rabbit corpus cavernosum: functional characterization of angiotensin II receptors.
- The worldwide prevalence and epidemiology of erectile dysfunction
- ACE2–angiotensin-(1–7)–Mas axis and oxidative stress in cardiovascular disease
- Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
Cited by
- Angiotensins as therapeutic targets beyond heart disease.
- Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.
- Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice
- Diminazene aceturate, an angiotensin-converting enzyme II activator, prevents gastric mucosal damage in mice: Role of the angiotensin-(1-7)/Mas receptor axis.
- Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation
- New agents modulating the renin-angiotensin-aldosterone system—Will there be a new therapeutic option?
- Apelin‐13 treatment enhances the stability of atherosclerotic plaques
- The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)
- Egg White-Derived Tripeptide IRW (Ile-Arg-Trp) Is an Activator of Angiotensin Converting Enzyme 2.
- Role of renin angiotensin system in ischemic preconditioning
- Characterization of the Renin-Angiotensin System in Aged Cavernosal Tissue and its Role in Penile Fibrosis.
- Multidisciplinary Approach to Treat Erectile Dysfunction
- Angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas receptor in gonadal and reproductive functions.
- Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism.
- Rapamycin Suppresses Penile NADPH Oxidase Activity to Preserve Erectile Function in Mice Fed a Western Diet
- Research trends and hotspots of COVID-19 impact on sexual function: A bibliometric analysis based on Web of Science
- Activation of Angiotensin-converting Enzyme 2 Protects Against Lipopolysaccharide-induced Glial Activation by Modulating Angiotensin-converting Enzyme 2/Angiotensin (1–7)/Mas Receptor Axis
- Diminazene aceturate uses different pathways to induce relaxation in healthy and atherogenic blood vessels.
- Local Shear Stress and Dyslipidemia Interfere with Actin Cyto-Skeleton and Lysosomal Organization Contributing to Vascular Fragility
- Histone deacetylase 6 inhibition prevents hypercholesterolemia-induced erectile dysfunction independent of changes in markers of autophagy
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