Identification of a splice variant of optineurin which is defective in autophagy and phosphorylation.
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Summary
An isoform of mouse optineurin is identified which is defective in cargo- selective and non-selective autophagy possibly due to loss of phosphorylation and impaired interaction with TBK1, which inhibits autophagosome formation in neuronal cells.
- Type
- article
- Published
- 2018-11-01
- Cited by
- 14
- References
- 50
- OpenAlex
- https://openalex.org/W2887102673
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:53526323
Keywords
Optineurin, Autophagy, Cell biology, Phosphorylation, Huntingtin
References
- Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation
- An Overview of the Molecular Mechanism of Autophagy
- Functional analysis of optineurin and some of its disease‐associated mutants
- Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene
- Defects in autophagy caused by glaucoma-associated mutations in optineurin.
- Preparation, culture, and immortalization of mouse embryonic fibroblasts.
- Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains
- CELLULAR AND MOLECULAR BIOLOGY OF OPTINEURIN
- Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP.
- Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β*
- Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates
- E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy
- Optineurin suppression causes neuronal cell death via NF‐κB pathway
- Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins.
- Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression.
- M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells
- Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
- Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection
- p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy*
- Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism
Cited by
- ULK1/2 Restricts the Formation of Inducible SINT-Speckles, Membraneless Organelles Controlling the Threshold of TBK1 Activation
- Optineurin promotes aggregation of mutant huntingtin and mutant ataxin-3, and reduces cytotoxicity of aggregates
- Optineurin modulates ER stress-induced signaling pathways and cell death.
- A glaucoma‐ and ALS‐associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress
- Phosphoproteomics analysis of diabetic cardiomyopathy in aging‐accelerated mice and effects of D‐pinitol
- Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice
- Optineurin mediates delivery of membrane from transferrin receptor-positive endosomes to autophagosomes
- Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s Disease
- ALS plasma reduces the viability of NSC34 cells via altering mRNA expression of VEGF: A short report
- Post-transcriptional dynamics and RNA homeostasis in autophagy and cancer
- Optineurin is involved in regulating macrophage responses during mycobacterial infection
- Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation.
- A cytoprotective role for optineurin during mycobacterial infection of macrophages
- Nutrient stress diverts RRN3 from rRNA transcription to alternative polyadenylation of autophagy mRNAs in ovarian cancer
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