CELLULAR AND MOLECULAR BIOLOGY OF OPTINEURIN
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Summary
The characteristics of optineurin are described and cellular and molecular biology investigations conducted so far on optineurin are summarized, indicating that optineurin is a cytosolic protein containing 577 amino acid residues.
- Type
- review
- Published
- 2012-01-01
- Cited by
- 132
- References
- 167
- Access
- Open access
- OpenAlex
- https://openalex.org/W1866075641
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13093128
Keywords
Optineurin, Biology, Cell biology, Huntingtin, Amyotrophic lateral sclerosis
References
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Cited by
- Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation
- Interactions moléculaires et cellulaires entre les protéines E3-14.7K, FIP-1 et les microtubules : application dans le transfert de gènes
- Characterisation of the Interaction between FAT10 and its Substrate Protein p62
- Optineurin: the Autophagy Connection
- Mechanizmy patogenetyczne stwardnienia bocznego zanikowego
- Le rôle de l’ubiquitination et des endomembranes dans l’activation du facteur de transcription NF-κB
- Functional analysis of optineurin and some of its disease‐associated mutants
- Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene
- Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells
- Defects in autophagy caused by glaucoma-associated mutations in optineurin.
- Identification of an Alu‐repeat‐mediated deletion of OPTN upstream region in a patient with a complex ocular phenotype
- An investigation into the role of optineurin in macrophage-mediated acute antibacterial response in inflammatory bowel disease.
- Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis
- Paget’s disease of bone: an osteoimmunological disorder?
- Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients
- E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy
- Loss of Optineurin In Vivo Results in Elevated Cell Death and Alters Axonal Trafficking Dynamics
- M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells
- Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression
- Genetics of primary open angle glaucoma
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