Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation
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Summary
This work reports the insulin-like growth factor 2 mRNA-binding proteins as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence and finds that IGF2BPs selectively bind to m 6A-containing mRNAs and promote their stability.
- Type
- article
- Published
- 2018-02-23
- Cited by
- 2,573
- References
- 65
- OpenAlex
- https://openalex.org/W2793785833
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3575886
Keywords
N6-Methyladenosine, Messenger RNA, RNA-binding protein, Translation (biology), Biology
References
- CRD-BP mediates stabilization of βTrCP1 and c-myc mRNA in response to β-catenin signalling
- Messenger RNA half-life measurements in mammalian cells.
- Structure and function of KH domains
- N6-methyladenosine Modulates Messenger RNA Translation Efficiency
- RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data
- Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies
- A conserved role for cytoplasmic poly(A)‐binding protein 1 (PABPC1) in nonsense‐mediated mRNA decay
- The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins.
- RNA stabilization by the AU‐rich element binding protein, HuR, an ELAV protein
- Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains
- m6A-dependent regulation of messenger RNA stability
- m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
- N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
- Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
- Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
- FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
- Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice.
- The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability
- m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
- Cutadapt removes adapter sequences from high-throughput sequencing reads
Cited by
- IGF2BP1 is the first positive marker for anaplastic thyroid carcinoma diagnosis
- LncRNA HCG11 mediated by METTL14 inhibits the growth of lung adenocarcinoma via IGF2BP2/LATS1.
- ZNF677 suppresses renal cell carcinoma progression through N6‐methyladenosine and transcriptional repression of CDKN3
- The role of N6-methyladenosine (m6A) in kidney diseases
- N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection
- An additional class of m6A readers
- Emerging Roles of N6-Methyladenosine on HIV-1 RNA Metabolism and Viral Replication
- Emerging role of dynamic RNA modifications during animal development.
- Structural Insights into N6-methyladenosine (m6A) Modification in the Transcriptome
- Binding specificities of human RNA binding proteins towards structured and linear RNA sequences
- YTH Domain: A Family of N6-methyladenosine (m6A) Readers
- RNA N6-methyladenosine modification in cancers: current status and perspectives
- Mechanism of N6-methyladenosine modification and its emerging role in cancer.
- Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
- Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells
- Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
- Joining the dots – protein‐RNA interactions mediating local mRNA translation in neurons
- N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development
- Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing
- The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′–3′ exoribonuclease XRN1
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