N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development
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Summary
The potential roles of m6A modification in human cancers and their underlying molecular mechanisms are described and potential therapeutic approaches are highlighted by targeting the key m 6A modification regulators for cancer drug development.
- Type
- review
- Published
- 2018-06-06
- Cited by
- 66
- References
- 112
- Access
- Open access
- OpenAlex
- https://openalex.org/W2807347076
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:53972363
Keywords
Demethylase, N6-Methyladenosine, Methyltransferase, Drug development, Biology
References
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Cited by
- Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A)
- RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
- N6-Methyladenosine (m6A): A Promising New Molecular Target in Acute Myeloid Leukemia
- m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation
- The N6‐methyladenosine (m6A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity‐associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma
- Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells.
- Recent developments of small molecules targeting RNA m6A modulators.
- RNA m6A methylation regulates sorafenib resistance in liver cancer through FOXO3‐mediated autophagy
- The m6A-Related mRNA Signature Predicts the Prognosis of Pancreatic Cancer Patients
- Mechanism of RNA modification N6-methyladenosine in human cancer
- Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection
- Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification.
- Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells
- Identification of Specific N6-methyladenosine RNA Demethylase FTO Inhibitors by Single Quantum Dot-Based FRET Nanosensor.
- N6‐methyladenosine (m6A) RNA modification in cancer stem cells
- Liver-on-a-chip platform to study anticancer effect of statin and its metabolites
- RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer
- Methyladenosine Modification in RNAs: Classification and Roles in Gastrointestinal Cancers
- Context-Dependent Roles of RNA Modifications in Stress Responses and Diseases
- The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis
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