The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′–3′ exoribonuclease XRN1
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Summary
YTHDC2 was recently found to promote a “fast-track” expression program for specific mRNAs, and the data suggest that YTH DC2 accomplishes this by recruitment of the RNA degradation machinery to regulate the stability of m6A-containing m RNAs and by utilizing its distinct RNA-binding domains to bridge interactions between m6a-containingmRNAs and the ribosomes to facilitate their efficient translation.
- Type
- article
- Published
- 2018-07-03
- Cited by
- 211
- References
- 71
- Access
- Open access
- OpenAlex
- https://openalex.org/W2809830493
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:49674282
Keywords
Biology, Exoribonuclease, RNA-binding protein, RNA, Translation (biology)
References
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- Dynamic m6A mRNA methylation directs translational control of heat shock response
- N6-methyladenosine Modulates Messenger RNA Translation Efficiency
- Cyclosporin A Associated Helicase-Like Protein Facilitates the Association of Hepatitis C Virus RNA Polymerase with Its Cellular Cyclophilin B
- The YTH Domain Is a Novel RNA Binding Domain*
- N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions
- Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification
- m6A-dependent regulation of messenger RNA stability
- A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
- The methylation state of poly A-containing messenger RNA from cultured hamster cells.
- The Synthesis of 2′-O-[(Triisopropylsilyl)oxy] methyl (TOM) Phosphoramidites of Methylated Ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for Use in Automated RNA Solid-Phase Synthesis
- Structures of the human and Drosophila 80S ribosome
- Modified nucleosides and bizarre 5′-termini in mouse myeloma mRNA
- Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain.
- The 3D rRNA modification maps database: with interactive tools for ribosome analysis
- High-resolution mapping reveals a conserved, widespread, dynamic meiotically regulated mRNA methylation program
Cited by
- The role of N6-methyladenosine (m6A) in kidney diseases
- N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection
- N6-Methyladenosine Role in Acute Myeloid Leukaemia
- The RNA Epitranscriptome of DNA Viruses
- N6-Methyladenosine Role in Cancer: Learning from AML
- Dynamic and reversible RNA N6‐methyladenosine methylation
- Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
- m6A modification of non-coding RNA and the control of mammalian gene expression.
- RNA helicases mediate structural transitions and compositional changes in pre-ribosomal complexes
- The m6A Writer: Rise of a Machine for Growing Tasks.
- m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins
- Understanding m6A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins
- Colocalization of m6A and G-Quadruplex-Forming Sequences in Viral RNA (HIV, Zika, Hepatitis B, and SV40) Suggests Topological Control of Adenosine N6-Methylation
- The Chemical Diversity of RNA Modifications
- N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction
- Epigenetic Methylations on N6-Adenine and N6-Adenosine with the same Input but Different Output
- Small changes, big implications: the impact of m6A RNA methylation on gene expression in pluripotency and development
- Regulation of Viral Infection by the RNA Modification N6-methyladenosine
- Marking RNA: m6A writers, readers, and functions in Arabidopsis
- Post-Transcriptional Regulation Of The Eulkaryotic Transcriptome By The Covalent Rna Modicication N6-Methyladenosine
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