The mechanisms of action of metformin
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Summary
Physiologically, metformin has been shown to reduce hepatic glucose production, yet not all of its effects can be explained by this mechanism and there is increasing evidence of a key role for the gut.
- Type
- review
- Published
- 2017-08-03
- Cited by
- 2,061
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W2743010525
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:100389
Keywords
Metformin, AMPK, Mechanism of action, Diabetes mellitus, Mechanism (biology)
References
- Evidence that the flux control coefficient of the respiratory chain is high during gluconeogenesis from lactate in hepatocytes from starved rats. Implications for the hormonal control of gluconeogenesis and action of hypoglycaemic agents.
- The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation: Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies
- Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
- Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non‐diabetic controls
- Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
- Control of gluconeogenesis by metformin: Does redox trump energy charge?
- 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
- Metformin activates duodenal AMPK and a neuronal network to lower glucose production
- Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
- Metformin and the intestine
- Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
- Importance of the intestine as a site of metformin‐stimulated glucose utilization
- Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
- Biomolecular mode of action of metformin in relation to its copper binding properties.
- AMPK - a nutrient and energy sensor that maintains energy homeostasis
- Clinical Pharmacokinetics of Metformin
- Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT3 receptors
- Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis
- Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin
- 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?
Cited by
- Diabetes-induced hypomagnesemia is not modulated by metformin treatment in mice
- Metformin inhibits proliferation and migration of endometrial cancer cells through regulating PI3K/AKT/MDM2 pathway.
- The pharmacogenetics of metformin
- Metformin: clinical use in type 2 diabetes
- 60 years of metformin use: a glance at the past and a look to the future
- New Evidence for the Mechanism of Action of a Type-2 Diabetes Drug Using a Magnetic Bead-Based Automated Biosensing Platform
- Metformin selectively targets redox control of complex I energy transduction
- Insulin Resistance and Hunger in Childhood Obesity: A Patient and Physician’s Perspective
- Metformin Potentiates the Benefits of Dietary Restraint: A Metabolomic Study
- Insulin Resistance: Any Role in the Changing Epidemiology of Thyroid Cancer?
- Diabetes, Hypertension, and Cardiovascular Disease: Clinical Insights and Vascular Mechanisms
- Chemoprevention of Gastric Cancer: Metformin
- Is metformin poised for a second career as an antimicrobial?
- Metformin monotherapy for adults with type 2 diabetes mellitus.
- Targeting of stress response pathways in the prevention and treatment of cancer.
- Pediatric Obesity: Influence on Drug Dosing and Therapeutics
- Homocysteine and Hyperhomocysteinaemia.
- Exploring novel human pancreatic alpha-amylase inhibitors : a departure from carbohydrate-based therapeutics
- Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
- Alternative mRNA Splicing in the Pathogenesis of Obesity
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