5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
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Summary
Treatment of hepatoma cells with 5-aminoimidazole-4-carboxamide riboside (AICAR), an agent that activates AMP-activated protein kinase (AMPK), mimics the ability of insulin to repress PEPCK gene transcription and suggests activation of AMPK would inhibit hepatic gluconeogenesis in an insulin-independent manner and thus help to reverse the hyperglycemia associated with type 2 diabetes.
- Type
- article
- Published
- 2000-06-01
- Cited by
- 406
- References
- 67
- Access
- Open access
- OpenAlex
- https://openalex.org/W1973749169
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2230209
Keywords
Gluconeogenesis, AMPK, Insulin, Insulin receptor, Biology
References
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- Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinase
- Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase.
- AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release.
- Regulation of gene expression by insulin.
- PEPCK Gene as Model of Inhibitory Effects of Insulin on Gene Transcription
- Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinase.
- 5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms (*)
- The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro.
- AMP-activated Protein Kinase Inhibits the Glucose-activated Expression of Fatty Acid Synthase Gene in Rat Hepatocytes*
- Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase*
- Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP.
- Cloning and sequencing of the 5′ region of the human glucose‐6‐phosphatase gene: transcriptional regulation by cAMP, insulin and glucocorticoids in H4IIE hepatoma cells
- The 5′‐AMP‐activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex
- Control of hepatic fatty acid oxidation by 5'-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism.
- Regulation of gene expression by insulin.
- AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.
- Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase.
- Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin
Cited by
- An mRNA Splice Variant of the AFX Gene with Altered Transcriptional Activity*
- Regulation of Fasted Blood Glucose by Resistin
- Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats.
- Yeast as a model system to study glucose-mediated signalling and response.
- Antidiabetic and Antihyperlipidemic Effects of Clitocybe nuda on Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice
- Combretum lanceolatum flowers ethanol extract inhibits hepatic gluconeogenesis: an in vivo mechanism study
- 2 型糖尿病マウスの肝臓における霊芝菌糸体培養培地抽出物 (WER) の糖質代謝に与える影響
- Preventive effect of salicin ether against type-2 diabetes mellitus through targeting PPARγ-regulated gene expression.
- Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals
- Implication des neurones exprimant NUCB2/nesfatine-1 dans la régulation de l'homéostasie énergétique
- Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations.
- Metformin: old wine in new bottle--evolving technology and therapy in diabetes.
- The role of amino acids in liver protein metabolism under a high protein diet : identification of amino acids signal and associated transduction pathways
- Alcohol intake modulates hormonal activity of adipose tissue.
- Cytokine Regulation of AMPK signalling.
- Expression, régulation et rôle du système adiponectine dans l'ovaire chez trois espèces
- The role of adipocyte CREB in insulin resistance
- Linking Environmental Toxicant Exposure To Diabetes Susceptibility
- Regulation of the Mechanistic Target of Rapamycin by Cellular Stress.
- The effect of metformin-induced AMPK activation on adipogenesis and HIV replication
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