Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
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Summary
It is concluded that ATM, a gene known to be involved in DNA repair and cell cycle control, plays a role in the effect of metformin upstream of AMP-activated protein kinase, and variation in this gene alters glycemic response to meetformin.
- Type
- article
- Published
- 2010-12-26
- Cited by
- 456
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W1937449199
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13772362
Keywords
Metformin, Type 2 diabetes, Glycemic, Medicine, Internal medicine
References
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- Electronic record linkage to create diabetes registers
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- Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation
- A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
- Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
- Ataxia Telangiectasia Mutated and p21CIP1 Modulate Cell Survival of Drug-Induced Senescent Tumor Cells: Implications for Chemotherapy
- Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.
- Cleavage site determinants in the mammalian polyadenylation signal.
- Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.
- Mapping the Genetic Architecture of Gene Expression in Human Liver
- Integrated detection and population-genetic analysis of SNPs and copy number variation
- A survey of genetic human cortical gene expression
- ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.
- Similar substrate recognition motifs for mammalian AMP‐activated protein kinase, higher plant HMG‐CoA reductase kinase‐A, yeast SNF1, and mammalian calmodulin‐dependent protein kinase I
- Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.
Cited by
- Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects
- Genetic variants in PARP1 (rs3219090) and IRF4 (rs12203592) genes associated with melanoma susceptibility in a Spanish population
- Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association.
- Manipulation du métabolisme énergétique dans les leucémies aiguës myéloïdes : mitochondrie, apoptose et mécanisme d'action de la metformine
- Metformine : le point sur les mécanismes d'action
- Metformine et aspirine : de « nouveaux » traitements du cancer ?
- [Pharmacogenetics of oral antidiabetic treatment].
- Insulin Signaling And Insulin Resistance
- Metformine et cancer : passé, présent, avenir
- Natural-agent mechanisms and early-phase clinical development.
- Genetics of Drug Response in Type 2 Diabetes
- Variability in pharmacological response to metformin treatment.
- 2．2型糖尿病における進歩；ゲノムワイド関連解析による疾患感受性遺伝子領域同定の成果
- [Potential sensitivity to metformin of the diabetics suffering and not suffering with cancer: a pharmacogenetic study].
- A Framework for the Multilevel Integration of Molecular, Clinical, and Population Data in the Context of Breast Cancer: Challenges and Considerations of Socioecological Conditions and Pharmacogenomics
- Clinical and genetic determinants of diabetic retinopathy
- Blood DNA methylation biomarkers for breast cancer risk
- Inhibition of tumor energy pathways for targeted esophagus cancer therapy.
- Genetics of Type 2 Diabetes and Clinical Utility
- Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes
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