Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target
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Summary
A marked decrease in adduction in the presence of MitoTEMPO demonstrated a primary role for mitochondrial superoxide in electrophile generation and indicated an important role for mitochondria as both a source and target of lipid electrophiles.
- Type
- article
- Published
- 2017-06-28
- Cited by
- 29
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2625179621
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1220864
Keywords
Mitochondrion, Electrophile, Chemistry, Cell biology, Biochemistry
References
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- WebGestalt: an integrated system for exploring gene sets in various biological contexts
- IRAK-1 Contributes to Lipopolysaccharide-induced Reactive Oxygen Species Generation in Macrophages by Inducing NOX-1 Transcription and Rac1 Activation and Suppressing the Expression of Antioxidative Enzymes*
- A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)
- Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease.
- Crosstalk between mitochondria and NADPH oxidases
- Lipid profiling reveals arachidonate deficiency in RAW264.7 cells: Structural and functional implications.
- Protein-Selective Capture to Analyze Electrophile Adduction of Hsp90 by 4-Hydroxynonenal
- Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems
- Global Analysis of Protein Damage by the Lipid Electrophile 4-Hydroxy-2-nonenal
- Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation.
- Heme Oxygenase-1 Couples Activation of Mitochondrial Biogenesis to Anti-inflammatory Cytokine Expression*
- 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis.
- mitochondrial pathway for biosynthesis of lipid mediators
Cited by
- Chemoproteomics Reveals Chemical Diversity and Dynamics of 4-Oxo-2-nonenal Modifications in Cells*
- Mitochondria Alkylation and Cellular Trafficking Mapped with a Lipophilic BODIPY-Acrolein Fluorogenic Probe.
- Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies
- Carbonyl scavengers as pharmacotherapies in degenerative disease: Hydralazine repurposing and challenges in clinical translation.
- Cholesterol secosterol aldehyde adduction and aggregation of Cu,Zn-superoxide dismutase: Potential implications in ALS
- Unbiased Identification of Proteins Covalently Modified by Complex Mixtures of Peroxidized Lipids Using a Combination of Electrophoretic Mobility Band Shift with Mass Spectrometry
- Proteomics and beyond: Cell decision-making shaped by reactive electrophiles
- Regulation of stress signaling pathways by protein lipoxidation
- 2-Alkenal modification of hemoglobin: Identification of a novel hemoglobin-specific alkanoic acid-histidine adduct
- REX technologies for profiling and decoding the electrophile signaling axes mediated by Rosetta Stone proteins
- Three pairs of enantiomers bearing mitochondria‐targeted TPP + groups as potential anti‐cancer agents
- Post-Translational Modification of Proteins Mediated by Nitro-Fatty Acids in Plants: Nitroalkylation
- Integrated approaches to unravel the impact of protein lipoxidation on macromolecular interactions.
- Arachidonic Acid Kills Staphylococcus aureus through a Lipid Peroxidation Mechanism
- Non-Enzymatic Lysine Lactoylation of Glycolytic Enzymes
- Carbon monoxide - beyond toxicity?
- Role of electrophilic nitrated fatty acids during development and response to abiotic stress processes in plants.
- Electrophilic oxysterols: generation, measurement and protein modification
- A not-so-ancient grease history: click chemistry and protein lipid modifications
- Staphylococcus aureus Peptide Methionine Sulfoxide Reductases Protect from Human Whole-Blood Killing
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