Protein-Selective Capture to Analyze Electrophile Adduction of Hsp90 by 4-Hydroxynonenal
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Summary
A targeted molecular probe approach was employed to study modifications of the molecular chaperone heat shock protein 90 (Hsp90), which regulates diverse client proteins and illustrates the utility of a protein-selective affinity capture approach for targeted analysis of electrophile adducts and their biological effects.
- Type
- article
- Published
- 2011-07-12
- Cited by
- 38
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2018089147
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17677465
Keywords
Hsp90, Chemistry, Geldanamycin, Heat shock protein, Biochemistry
References
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- Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II.
- Mutational analysis of hsp90 binding to the progesterone receptor.
- Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3.
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
- IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal.
- IDPicker 2.0: Improved Protein Assembly with High Discrimination Peptide Identification Filtering
- Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation
- Mechanism-based profiling of enzyme families.
- Data-controlled automation of liquid chromatography/tandem mass spectrometry analysis of peptide mixtures
- Covalent adduction of human serum albumin by 4-hydroxy-2-nonenal: kinetic analysis of competing alkylation reactions.
- Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases.
- An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database
- P-Mod: an algorithm and software to map modifications to peptide sequences using tandem MS data.
- Heat Shock Factor 1 Attenuates 4-Hydroxynonenal-mediated Apoptosis
- Global Analysis of Protein Damage by the Lipid Electrophile 4-Hydroxy-2-nonenal
- The Hsp90 molecular chaperone: an open and shut case for treatment.
- Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
- Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal.
- Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.
Cited by
- Targeted Protein Capture for Analysis of Electrophile-Protein Adducts
- 4-Hydroxy-nonenal—A Bioactive Lipid Peroxidation Product
- Quantitative Chemoproteomics for Site-Specific Analysis of Protein Alkylation by 4-Hydroxy-2-Nonenal in Cells
- Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid
- Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems
- The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response
- Oxidative stress mediated aldehyde adduction of Grp78 in a mouse model of alcoholic liver disease: Functional independence of ATPase activity and chaperone function
- Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise
- Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection.
- Peptidyl-prolyl cis/trans-Isomerase A1 (Pin1) Is a Target for Modification by Lipid Electrophiles
- Protein Modification by Oxidized Phospholipids and Hydrolytically Released Lipid Electrophiles: Investigating Cellular Responses
- Chaperone Heat Shock Protein 90 Mobilization and Hydralazine Cytoprotection against Acrolein-Induced Carbonyl Stress
- Protein modification by aldehydophospholipids and its functional consequences
- Chemoproteomic profiling of protein modifications by lipid-derived electrophiles.
- Role of reactive lipid mediators in oxidative stress-induced toxicity
- Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes
- Free Radical Biology and Medicine
- The Die Is Cast: Precision Electrophilic Modifications Contribute to Cellular Decision Making
- Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling
- Antioxidants and HNE in redox homeostasis.
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