Biomolecular condensates: organizers of cellular biochemistry
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Summary
This work has shown that liquid–liquid phase separation driven by multivalent macromolecular interactions is an important organizing principle for biomolecular condensates and has proposed a physical framework for this organizing principle.
- Type
- review
- Published
- 2017-02-22
- Cited by
- 5,353
- References
- 128
- Access
- Open access
- OpenAlex
- https://openalex.org/W2590568317
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37694361
Keywords
Biogenesis, Nucleic acid, Function (biology), Ribosome, RNA
References
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- Polymer physics of intracellular phase transitions
- Phase Transitions of Spindle-Associated Protein Regulate Spindle Apparatus Assembly
- Residue-by-residue view of in vitro FUS granules that bind the C-terminal domain of RNA polymerase II
- A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.
- RNA transcription modulates phase transition-driven nuclear body assembly
- Enzyme clustering accelerates processing of intermediates through metabolic channeling
- Direct Visualization of the Co-transcriptional Assembly of a Nuclear Body by Noncoding RNAs
- Quantitative characterization of intrinsic disorder in polyglutamine: insights from analysis based on polymer theories.
- A role for Q/N-rich aggregation-prone regions in P-body localization
Cited by
- RGG/RG Motif Regions in RNA Binding and Phase Separation.
- The SUMO Conjugation Complex Self-Assembles into Nuclear Bodies Independent of SIZ1 and COP11[OPEN]
- Biomolecular Chemistry in Liquid Phase Separated Compartments
- Compartmentalizing Cell-Free Systems: Toward Creating Life-Like Artificial Cells and Beyond.
- New Evidence of the Importance of Weak Interactions in the Formation of PML-Bodies
- Human de novo Purine Biosynthesis
- RNA stores tau reversibly in complex coacervates
- Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila.
- A phase separation model predicts key features of transcriptional control
- Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase
- ATP controls the crowd
- The advantage of channeling nucleotides for very processive functions
- Neurodegenerative disease: RNA repeats put a freeze on cells
- Reentrant phase transition drives dynamic substructure formation in ribonucleoprotein droplets
- Structural Basis for Mitotic Centrosome Assembly in Flies
- Reconstitution of the oocyte nucleolus in mice through a single nucleolar protein, NPM2
- Disordered Proteins: Connecting Sequences to Emergent Properties
- Molecular biology: A liquid reservoir for silent chromatin
- Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
- RNA gets in phase
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