Polymer physics of intracellular phase transitions
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Summary
These findings highlight the relevance of classical concepts from the physics of polymeric phase transitions for understanding the assembly of intracellular membrane-less compartments, and challenge the challenge of applying these concepts given the heteropolymeric nature of protein sequences, the complex intrACEllular environment, and non-equilibrium features intrinsic to cells.
- Type
- article
- Published
- 2015-11-01
- Cited by
- 1,365
- References
- 72
- OpenAlex
- https://openalex.org/W1912455695
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4643961
Keywords
Intracellular, Organelle, Membrane, Compartment (ship), Phase (matter)
References
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Cited by
- RGG/RG Motif Regions in RNA Binding and Phase Separation.
- Biomolecular Chemistry in Liquid Phase Separated Compartments
- New Evidence of the Importance of Weak Interactions in the Formation of PML-Bodies
- Phase separation in biology; functional organization of a higher order
- Phase Separation: Linking Cellular Compartmentalization to Disease.
- Superparamagnetism of tryptophan and walk memory of proteins
- Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease
- A Structure and Dynamics Continuum of Higher-Order Assemblies: Amyloids, Signalosomes and Granules
- Membraneless organelles: Phasing in and out.
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- A glass menagerie of low complexity sequences
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- Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein
- Ephemeral protein binding to DNA shapes stable nuclear bodies and chromatin domains
- Liquid-liquid phase separation in cellular signaling systems.
- Are aberrant phase transitions a driver of cellular aging?
- Distinct stages in stress granule assembly and disassembly
- RNA-Based Coacervates as a Model for Membraneless Organelles: Formation, Properties, and Interfacial Liposome Assembly.
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