Synthesis of Several Types of Bridged Nucleic Acids
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Summary
A number of bridged nucleic acids with conformationally locked sugar moiety were synthesized from the readily accessible sugar derivatives, summarizes the synthesis of these nucleic acid analogues.
- Type
- article
- Published
- 2009-04-25
- Cited by
- 12
- References
- 51
- OpenAlex
- https://openalex.org/W2011393572
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:84759273
Keywords
Chemistry, Nucleic acid, Combinatorial chemistry, Nanotechnology, Biochemistry
References
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- 2'-O,4'-C-Methylene bridged nucleic acid (2',4'-BNA): synthesis and triplex-forming properties.
- Double‐Stranded DNA‐Templated Oligonucleotide Digestion Triggered by Triplex Formation
- Recognition of T.A interruption by 2',4'-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation.
- Design, synthesis, and properties of 2',4'-BNA(NC): a bridged nucleic acid analogue.
- N-Methyl substituted 2',4'- BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization.
- Design, synthesis, and evaluation of a novel bridged nucleic acid, 2',5'-BNAON, with S-type sugar conformation fixed by N-O linkage
- Triplex-forming enhancement with high sequence selectivity by single 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA) modification
- Synthesis and conformation of 3′,4′-BNA monomers, 3′-O,4′-C-methyleneribonucleosides
- A bridged nucleic acid, 2′,4′-BNACOC: synthesis of fully modified oligonucleotides bearing thymine, 5-methylcytosine, adenine and guanine 2′,4′-BNACOC monomers and RNA-selective nucleic-acid recognition
- The RNAi revolution
- 2'-O,4'-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug.
- LNA: a versatile tool for therapeutics and genomics.
- Development of a novel nucleoside analogue with S-type sugar conformation: 2′-deoxy-trans-3′,4′-bridged nucleic acids
- On the in vitro and in vivo Properties of Four Locked Nucleic Acid Nucleotides Incorporated into an Anti‐H‐Ras Antisense Oligonucleotide
- 4'-Substituted nucleosides. 4. Synthesis of some 4'-hydroxymethyl nucleosides
- Nucleoside 4',5'-enol acetates. Synthesis and chemistry of a unique uridine O2,4'-anhydronucleoside
- Antisense-Oligonucleotide – ein universelles Therapieprinzip
- Effective synthesis of C-nucleosides with 2′,4′-BNA modification
- Antisense technologies. Improvement through novel chemical modifications.
Cited by
- A firmly hybridizable, DNA-like architecture with DAD/ADA- and ADD/DAA-type nonnatural base pairs as an extracellular genetic candidate.
- Synthesis and biological evaluation of 2′,4′- and 3′,4′-bridged nucleoside analogues
- Synthesis, RNA selective hybridization and high nuclease resistance of an oligonucleotide containing novel bridged nucleic acid with cyclic urea structure.
- Bridged Nucleic Acids: Development, Synthesis and Properties
- Synthesis and hybridization property of a boat-shaped pyranosyl nucleic acid containing an exocyclic methylene group in the sugar moiety.
- Bridged nucleic acid conjugates at 6'-thiol: synthesis, hybridization properties and nuclease resistances.
- Synthesis and properties of a bridged nucleic acid with a perhydro-1,2-oxazin-3-one ring.
- Synergy of Two Highly Specific Biomolecular Recognition Events: Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA.
- [Design, syntheses and properties of nucleic Acid switch in response to external stimuli].
- Synthesis, in vivo and in silico analgesic and anti-inflammatory studies of α-D-ribofuranose derivatives
- Self-assembled nanogels from polysaccharides grafted with short oligonucleotides: control of size and thermoresponsiveness
- 2′,4′-Bridged Nucleic Acids Containing Plural Heteroatoms in the Bridge Moiety
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