Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers

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Summary

It is shown that intrinsically disordered, repeat proteins can be designed to exhibit tunable lower or upper critical solution temperature transitions in physiological solutions and that mutation of key residues at the repeat level abolishes phase behaviour or encodes an orthogonal transition.

Type
article
Published
2015-09-21
Cited by
394
References
57
Access
Open access

Keywords

Upper critical solution temperature, Lower critical solution temperature, Polymer, Sequence (biology), Proteome

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