Reduced Number of Hypocretin Clinical Study Neurons in Human Narcolepsy
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Summary
It is shown that human neurons are immunostained for Hcrt, and narcoleptics have an 85%–95% reduction in the num- Tocontrolforthetimespentinfix, weprocessed three ber of Hcrt neurons.
- Type
- article
- Published
- 2000-01-01
- Cited by
- 1,875
- References
- 23
- OpenAlex
- https://openalex.org/W2555061979
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5961605
Keywords
Narcolepsy, Orexin, Psychology, Neuroscience, Endocrinology
References
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- Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs.
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- Interaction of the hypocretins with neurotransmitters in the nucleus accumbens.
- Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP‐expressing locus coeruleus
- Induction of active (REM) sleep and motor inhibition by hypocretin in the nucleus pontis oralis of the cat.
- Hypocretin (orexin) levels in cerebrospinal fluid of patients with narcolepsy: relationship to cataplexy and HLA DQB1*0602 status.
- Roles of orexins in the regulation of feeding and arousal.
- Excitotoxic degeneration of hypothalamic orexin neurons in slice culture.
- Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity
- GABA‐mediated control of hypocretin‐ but not melanin‐concentrating hormone‐immunoreactive neurones during sleep in rats
- Volume of the amygdala is reduced in patients with narcolepsy - a structural MRI study.
- Parkinson's disease, sleepiness and hypocretin/orexin.
- Hypocretin-2 Saporin Lesions of the Ventrolateral Periaquaductal Gray (vlPAG) Increase REM Sleep in Hypocretin Knockout Mice
- Activation of Bombesin Receptor Subtype-3 Influences Activity of Orexin Neurons by Both Direct and Indirect Pathways
- Olfactory dysfunction in narcolepsy with and without cataplexy.
- Hypocretin1/OrexinA axon targeting of laterodorsal tegmental nucleus neurons projecting to the rat medial prefrontal cortex.
- Altered Circadian Rhythm of Melatonin Concentrations in Hypocretin-Deficient Men
- The hypocretins and the reward function: what have we learned so far?
- Headache and sleep: Shared pathophysiological mechanisms