Insomnia following hypocretin2-saporin lesions of the substantia nigra.
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Summary
In these rats, a nearly complete loss of both tyrosine hydroxylase and neuron-specific nuclear protein (neuronal nuclei) immunoreactive cells in the substantia nigra as well as diminution of tyrosin hydroxyase-immunoreactive fibers in the caudate putamen was found.
- Type
- article
- Published
- 2006-01-01
- Cited by
- 55
- References
- 44
- OpenAlex
- https://openalex.org/W2040810583
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24570884
Keywords
Substantia nigra, Ventral tegmental area, Tegmentum, Tyrosine hydroxylase, Wakefulness
References
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- Behavioral state instability in orexin knockout mice
- Cholinergic and non-cholinergic neurons in the rat pedunculopontine tegmental nucleus
- Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro.
- Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and walking in the rat.
- Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes.
- Connections of the mesencephalic locomotor region (MLR) I. Substantia nigra afferents.
- Motor behavioural changes after intracerebroventricular injection of 6-hydroxydopamine in the rat: an animal model of Parkinson's disease.
- Role of the substantia nigra pars reticulata in sensorimotor gating, measured by prepulse inhibition of startle in rats.
- Pedunculopontine tegmental nucleus of the rat: Cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum
- Nigral innervation of cholinergic and glutamatergic cells in the rat mesopontine tegmentum: Light and electron microscopic anterograde tracing and immunohistochemical studies
- Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats.
- Differential expression of orexin receptors 1 and 2 in the rat brain
Cited by
- The Hypocretin/Orexin System: An Increasingly Important Role in Neuropsychiatry
- Role of Basal Ganglia in Sleep–Wake Regulation: Neural Circuitry and Clinical Significance
- Nigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep.
- Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule
- Sleep and energy balance: Interactive homeostatic systems.
- Role of the basal ganglia in the control of sleep and wakefulness
- CONTROL OF SLEEP AND WAKEFULNESS
- Modeling sleep alterations in Parkinson's disease: How close are we to valid translational animal models?
- The Dopaminergic System of the Telencephalo-Diencephalic Areas of the Vertebrate Brain in the Organization of the Sleep–Waking Cycle
- Neuropeptidergic Mediators of Spontaneous Physical Activity and Non-Exercise Activity Thermogenesis
- Perspectives on the rapid eye movement sleep switch in rapid eye movement sleep behavior disorder
- Neural circuitry of stress-induced insomnia in rats
- How do the basal ganglia regulate sleep-wake behavior?
- Neurotoxic lesions at the ventral mesopontine junction change sleep time and muscle activity during sleep: an animal model of motor disorders in sleep.
- Optogenetic Deconstruction of Sleep–Wake Circuitry in the Brain
- Basic sleep mechanisms: an integrative review.
- Physiology of the orexinergic/hypocretinergic system: a revisit in 2012.
- Basal ganglia control of sleep–wake behavior and cortical activation
- Candidature pour l'obtention de l'habilitation à diriger des recherches présentée et soutenue par Laurent BRONDEL le 5 décembre 2011
- revisit in 2012 Physiology of the orexinergic/hypocretinergic system: a
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