Narcolepsy and the HLA region.
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Summary
Recent result suggests that human narcolepsy is associated with the destruction of a small number of hypothalamic neurons containing the peptide hypocretins (orexins), consistent with an immune destruction of hypocretin-containing cells as the most common etiology for human narCOlepsy.
- Type
- article
- Published
- 2001-07-02
- Cited by
- 127
- References
- 86
- OpenAlex
- https://openalex.org/W11431000
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23893598
Keywords
Induction motor, Rotor (electric), Control theory (sociology), Control engineering, Computer science
References
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- Family studies in narcolepsy.
- DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans.
- Handbook of sleep disorders
- DQB1*0602 confers genetic susceptibility to multiple sclerosis in Afro-Brazilians.
- A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
- Sleep: A Physiologic Role for IL‐1β and TNF‐α a
- HLA class II association with rheumatoid arthritis: facts and interpretations.
- Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
- Major Histocompatibility Class II Molecules in the CNS: Increased Microglial Expression at the Onset of Narcolepsy in a Canine Model
- Sleep/Wake Disorders: Natural History, Epidemiology, and Long-Term Evolution.
- Microsatellite single nucleotide polymorphisms in the HLA-DQ region.
- Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy
- Genetic and familial aspects of narcolepsy
- CSF immune variables in patients with narcolepsy
- COMPLEXITY IN THE MAJOR HISTOCOMPATIBILITY COMPLEX
- Possible association between HLA-B7 and narcolepsy.
- Hypocretin/orexin, sleep and narcolepsy
Cited by
- Hypocretin (orexin) levels in cerebrospinal fluid of patients with narcolepsy: relationship to cataplexy and HLA DQB1*0602 status.
- Orexins and their receptors: structural aspects and role in peripheral tissues
- Excitotoxic degeneration of hypothalamic orexin neurons in slice culture.
- Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity
- Narcolepsy and Idiopathic Hypersomnia
- Genetic aspects of parasomnias
- The importance of HLA DQB1*0602 typing in Slovene patients with narcolepsy.
- Animal models of sleep disorders.
- Genetische Aspekte der REM-Schlaf-Verhaltensstörung
- Sleep disorders : diagnosis, management and treatment : a handbook for clinicians
- Evidence for metabolic hypothalamo-amygdala dysfunction in narcolepsy.
- Importancia de las hipocretinas en la patogenia de la narcolepsia (breve revisión)
- Vergleich von drei genetischen Suszeptibilitätsmarkern zwischen Patienten mit idiopathischem Parkinson-Syndrom und deren direkten Verwandten mit Hilfe des Transmission Disequilibrium Tests for Siblings
- Juvenile myoclonic epilepsy and narcolepsy: A series of three cases.
- Plasma levels of tumor necrosis factor alpha and soluble tumor necrosis factor receptors in patients with narcolepsy.
- Animal Models of Narcolepsy
- Narcolepsy: immunological aspects.
- Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients
- Expression of class II major histocompatibility complex molecules on thyrocytes does not cause spontaneous thyroiditis but mildly increases its severity after immunization.
- Understanding narcolepsy, part 1: Epidemiology and neurophysiology
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