Elevated expression of ZNF217 promotes prostate cancer growth by restraining ferroportin-conducted iron egress
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Summary
It is underscored that elevated expression of ZNF217 promotes prostate cancer growth by restraining FPN-conducted iron egress by restraining the FPN expression and their iron–related activities.
- Type
- article
- Published
- 2016-10-19
- Cited by
- 26
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W2535687662
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3459019
Keywords
Ferroportin, Repressor, Intracellular, Cancer research, Downregulation and upregulation
References
- The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas
- The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells.
- Prognostic significance of ZNF217 expression in gastric carcinoma.
- Iron homeostasis and anemia markers in early breast cancer.
- Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha
- DNA methylation in glioblastoma: impact on gene expression and clinical outcome
- Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.
- Silencing of ZNF217 gene influences the biological behavior of a human ovarian cancer cell line.
- Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.
- The Multi-zinc Finger Protein ZNF217 Contacts DNA through a Two-finger Domain*
- Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux.
- Roles of the hepcidin–ferroportin axis and iron in cancer
- Identification of Genes Directly Regulated by the Oncogene ZNF217 Using Chromatin Immunoprecipitation (ChIP)-Chip Assays*
- MiR-203 Suppresses ZNF217 Upregulation in Colorectal Cancer and Its Oncogenicity
- TGF-β-dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex.
- Disordered signaling governing ferroportin transcription favors breast cancer growth.
- Myeloid zinc-finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress
- Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors
- Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence
- Coexistence of Copy Number Increases of c-Myc, ZNF217, CCND1, ErbB1 and ErbB2 in Ovarian Cancers
Cited by
- Genetic and epigenetic silencing of mircoRNA-506-3p enhances COTL1 oncogene expression to foster non-small lung cancer progression
- Functional and therapeutic significance of EZH2 in urological cancers
- The Emerging Role of Zfp217 in Adipogenesis
- Anticancer Activities of Ferrous and Ferric Ions in Progression, Proliferation, Angiogenesis, Invasion and Metastasis against Cancer and Tumor Cells
- Iron Metabolism in Prostate Cancer; From Basic Science to New Therapeutic Strategies
- Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer
- Research progress of ferroptosis and urinary tumors
- Iron in the Tumor Microenvironment.
- Long non-coding RNA CTBP1-AS2 enhances cervical cancer progression via up-regulation of ZNF217 through sponging miR-3163
- A Novel 10-Gene Signature Predicts Poor Prognosis in Low Grade Glioma
- A Novel Ferroptosis-Related Gene Model for Overall Survival Predictions of Bladder Urothelial Carcinoma Patients
- Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders
- Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It
- The Role of Iron in Cancer Progression
- MicroRNA-135 inhibits initiation of epithelial-mesenchymal transition in breast cancer by targeting ZNF217 and promoting m6A modification of NANOG
- Roles of Myc‐associated zinc finger protein in malignant tumors
- Overexpression of SLC40A1 inhibits the malignancy of hepatocellular carcinoma MHCC-97H cells by stimulation of autophagy
- Interferon regulatory factor 5-induced upregulation of zinc-finger protein 217 promotes pancreatic carcinoma progression
- The Intricate Interplay between the ZNF217 Oncogene and Epigenetic Processes Shapes Tumor Progression
- ZNF217: An Oncogenic Transcription Factor and Potential Therapeutic Target for Multiple Human Cancers
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