Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages.
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Summary
It is demonstrated genetically that a redox-sensitive transcription factor, Nrf2, regulates Fpn1 mRNA expression in macrophages and suggested that NRF2 may control iron metabolism during inflammation.
- Type
- article
- Published
- 2011-04-01
- Cited by
- 211
- References
- 53
- OpenAlex
- https://openalex.org/W1969945682
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35372146
Keywords
Ferroportin, Lipopolysaccharide, Hepcidin, Chemistry, Erythropoiesis
References
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- A physiological model to study iron recycling in macrophages.
- Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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- Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages.
- Role of NRF2 in protection against hyperoxic lung injury in mice.
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- The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.
- NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development.
- Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease.
Cited by
- MicroRNA Function in Cellular Stress Response
- Régulation de l'hepcidine et le rôle de la lipocaline 2 dans l'homéostasie du fer / Novel insights into the regulation of hepcidin and the role of lipocalin 2 in iron homeostasis
- Suppression of antioxidant Nrf-2 and downstream pathway in H9c2 cells by advanced glycation end products (AGEs) via ERK phosphorylation.
- Role of Nrf2 in the pathogenesis of atherosclerosis.
- Decrease in APP and CP mRNA expression supports impairment of iron export in Alzheimer's disease patients.
- Dysregulated expression of fatty acid oxidation enzymes and iron‐regulatory genes in livers of Nrf2‐null mice
- Macrophages: central regulators of iron balance.
- Ferroportin-mediated iron transport: expression and regulation
- Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis
- Hepcidin and Ferroportin: The New Players in Iron Metabolism
- NRF2-regulation in brain health and disease: implication of cerebral inflammation
- A combined iron and thyroid hormone protocol suppresses ischemia-reperfusion injury in rat livers
- Contrasting regulation of macrophage iron homeostasis in response to infection with Listeria monocytogenes depending on localization of bacteria.
- Iron homeostasis in astrocytes and microglia is differentially regulated by TNF‐α and TGF‐β1
- Alterations in renal iron metabolism caused by a copper/zinc-superoxide dismutase deficiency
- Exercise reduces inflammation and oxidative stress in obesity-related liver diseases.
- Nrf2 activation in the liver of rats subjected to a preconditioning sub-chronic iron protocol.
- Iron regulates the expression of ferroportin 1 in the cultured hFOB 1.19 osteoblast cell line
- Pro-inflammatory cytokine-mediated ferroportin down-regulation contributes to the nigral iron accumulation in lipopolysaccharide-induced Parkinsonian models.
- Cell-Type Specific Determinants of NRAMP1 Expression in Professional Phagocytes
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