Regulation of Cellular Immune Responses in Sepsis by Histone Modifications.
Explore this paper's citation graph
Summary
This review will argue for the use of chromatin modifications and CME expression in leukocytes as potential biomarkers of immunosuppression in patients with severe sepsis.
- Type
- article
- Published
- 2017-01-01
- Cited by
- 18
- References
- 125
- OpenAlex
- https://openalex.org/W2521567171
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41204259
Keywords
Sepsis, Proinflammatory cytokine, Immunology, Immune system, Chromatin
References
- Immune privilege in sites of chronic infection: Leishmania and regulatory T cells
- Sustained and incomplete recovery of naïve CD8+ T-cell precursors after sepsis contributes to impaired CD8+ T-cell responses to infection
- Epigenetics in sepsis: targeting histone deacetylases.
- Sepsis-induced apoptosis of the thymocytes in mice.
- Impaired CD4+ T cell proliferation and effector function correlates with repressive histone methylation events in a mouse model of severe sepsis
- The epigenetics of early development: Inferences from stem cells
- Circulating Cytokine/Inhibitor Profiles Reshape the Understanding of the SIRS/CARS Continuum in Sepsis and Predict Mortality1
- Neutrophil extracellular traps (NETs): Double-edged swords of innate immunity
- Changes in dendritic cell function in the immune response to sepsis
- Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25− lymphocytes
- Sepsis leads to a reduced antigen‐specific primary antibody response
- Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model
- A brief histone in time: understanding the combinatorial functions of histone PTMs in the nucleosome context.
- Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans1
- Genomewide Histone H3 Lysine 9 Acetylation Profiling in CD4+ T Cells Revealed Endoplasmic Reticulum Stress Deficiency in Patients with Acute‐on‐chronic Liver Failure
- Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T cell responses during pulmonary viral infection
- Molecular and cellular aspects of sepsis-induced immunosuppression
- Host innate immune responses to sepsis
- The Role of Regulatory T Cells in the Pathogenesis of Sepsis and Its Clinical Implication
- Inhibition of histone deacetylation enhances endotoxin-stimulated transcription but does not reverse endotoxin tolerance
Cited by
- From traditional biochemical signals to molecular markers for detection of sepsis after burn injuries.
- Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?
- Abrogated Caveolin-1 expression via histone modification enzyme Setdb2 regulates brain edema in a mouse model of influenza-associated encephalopathy
- MORPHOLOGY OF NASAL POLYPS IN PATIENTS WITH ALTERED IMMUNOLOGICAL REACTIVITY
- Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition
- Epigenetic modification via H3K4me3 and H3K9ac in human placenta is reduced in preeclampsia.
- Sepsis, immunosuppression and the role of epigenetic mechanisms
- Cytokine release syndrome in COVID-19: a major mechanism of morbidity and mortality
- COVID-19-Associated Acute Brain Dysfunction Related to Sepsis
- Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype
- Histones: The critical players in innate immunity
- Advances in the Study of Immunosuppressive Mechanisms in Sepsis
- The Epigenetics of Sepsis: How Gene Modulation Shapes Outcomes
- Altered histone modifications in Aedes aegypti midguts following Rift Valley fever virus exposure
- Atherosclerosis
- Cellular Inflammatory Responses
- Pathoepigenetics: The Role of Epigenetic Biomarkers in Disease Pathogenesis
Related papers
- Glimpses of the epigenetic landscape.
- Chromatin proteins and modifications as drug targets
- Inflammation, HIF-1, and the Epigenetics That Follows
- Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells
- A tale of metabolites: the crosstalk between chromatin and energy metabolism
- Epigenetic regulation of hypoxia‐responsive gene expression: Focusing on chromatin and DNA modifications
- Crop epigenetics and the molecular hardware of genotype × environment interactions
- Approaching the molecular and physiological function of macroH2A variants
- macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma
- Epigenetische Regulation in der Sepsis