Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T cell responses during pulmonary viral infection
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Summary
A novel activation role for the TGFβ-inducible SMYD3 in regulating iTreg cell formation leading to increased severity of virus-related disease is highlighted.
- Type
- review
- Published
- 2015-02-11
- Cited by
- 309
- References
- 165
- Access
- Open access
- OpenAlex
- https://openalex.org/W1962764685
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7554086
Keywords
Immune system, Innate lymphoid cell, FOXP3, Immunology, Biology
References
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- Bacterial-Reactive T Regulatory Cells Inhibit Pathogenic Immune Responses to the Enteric Flora1
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- Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.
- IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease.
- EZH2 and Histone 3 Trimethyl Lysine 27 Associated with Il4 and Il13 Gene Silencing in TH1 Cells*
Cited by
- Actinobacteria: A relevant minority for the maintenance of gut homeostasis.
- Interplay of Na+ Balance and Immunobiology of Dendritic Cells
- The role of Th17 and Treg responses in the pathogenesis of RSV infection
- FOXP3+ Treg Cells and Gender Bias in Autoimmune Diseases
- The joint power of sex and stress to modulate brain–gut–microbiota axis and intestinal barrier homeostasis: implications for irritable bowel syndrome
- T cells, teeth and tissue destruction - what do T cells do in periodontal disease?
- miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD
- Lactobacillus plantarum NCIMB8826 ameliorates inflammation of colon and skin in human APOC1 transgenic mice.
- SMYD3 stimulates EZR and LOXL2 transcription to enhance proliferation, migration, and invasion in esophageal squamous cell carcinoma.
- Divalent metal-ion transporter 1 is decreased in intestinal epithelial cells and contributes to the anemia in inflammatory bowel disease
- Open Peer Review
- ASCA, ANCA, ALCA and Many More: Are They Useful in the Diagnosis of Inflammatory Bowel Disease?
- For Whom the Bell Tolls (and Nods): Spit-acular Saliva
- Novel perspectives on therapeutic modulation of the gut microbiota
- Sjögren’s syndrome-associated microRNAs in CD14+ monocytes unveils targeted TGFβ signaling
- MD-1 deficiency attenuates dextran sodium sulfate (DSS)-induced colitis through modulating the function of colonic lamina propria dendritic cells.
- Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis
- Smyd5 plays pivotal roles in both primitive and definitive hematopoiesis during zebrafish embryogenesis
- The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases
- B Cell-Activating Factor (BAFF) in Inflammatory Bowel Disease: BAFFling No Longer?
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