Sepsis leads to a reduced antigen‐specific primary antibody response
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Summary
It is demonstrated that CLP markedly altered subsequent B‐cell responses, and adoptive transfer of naïve CD4+ T cells, naïve B cells, or naïve DCs did not rescue the antigen‐specific antibody response.
- Type
- article
- Published
- 2012-02-01
- Cited by
- 52
- References
- 49
- OpenAlex
- https://openalex.org/W1852572128
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23704965
Keywords
Biology, Immunology, Adoptive cell transfer, Antigen, T cell
References
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- Peripheral development of B cells in mouse and man
- Long-term survival and function after suspected gram-negative sepsis.
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- Myeloid-derived-suppressor cells as regulators of the immune system
- Interleukin-12 and the regulation of innate resistance and adaptive immunity
- Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1‐type immune response
- POLYMICROBIAL SEPSIS INDUCES DIVERGENT EFFECTS ON SPLENIC AND PERITONEAL DENDRITIC CELL FUNCTION IN MICE
- Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.
- The contribution of cd4+cd25+ T-regulatory-cells to immune suppression in sepsis
- Treatment of experimental sepsis-induced immunoparalysis with TNF.
- The relationship between sialic acid content and peanut agglutinin binding on senescent and enzyme treated human erythrocytes.
Cited by
- TNF and regulatory T cells are critical for sepsis‐induced suppression of T cells
- MicroRNA-19a and CD22 Comprise a Feedback Loop for B Cell Response in Sepsis
- Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis
- Long-term oncologic outcome after laparoscopic surgery for rectal cancer
- Immunosuppression after Sepsis: Systemic Inflammation and Sepsis Induce a Loss of Naïve T-Cells but No Enduring Cell-Autonomous Defects in T-Cell Function
- Early adaptive immune suppression in children with septic shock: a prospective observational study
- Complement C3 depletion links to the expansion of regulatory T cells and compromises T-cell immunity in human abdominal sepsis: a prospective pilot study.
- Experimental Sepsis Impairs Humoral Memory in Mice
- TNFR2 maintains adequate IL-12 production by dendritic cells in inflammatory responses by regulating endogenous TNF levels
- Presence of hypogammaglobulinemia - a risk factor of mortality in patients with severe sepsis, septic shock, and SIRS.
- Myeloid-Derived Suppressor Cells in Sepsis
- Novel insights for high mobility group box 1 protein-mediated cellular immune response in sepsis: A systemic review.
- Impact of sepsis on CD4 T cell immunity
- Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding.
- Efecto inmunomodulador del ácido All-Trans Retinoico (ATRA) como estrategia para la reversión de la inmunosupresión asociada a procesos infecciosos en un modelo murino
- Adaptive immune function in critical illness
- FACULDADE DE CIÊNCIAS FARMACÊUTICAS Programa de Pós-Graduação em Farmácia Área de Análises Clínicas Estudo da sepse experimental em animais diabéticos e sadios, tratados ou não com insulina
- Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice
- Annexin A2 Modulates ROS and Impacts Inflammatory Response via IL-17 Signaling in Polymicrobial Sepsis Mice
- Regulation of Cellular Immune Responses in Sepsis by Histone Modifications.
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