Mitochondria and Cancer
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Summary
Understanding mechanisms of mitochondrial misregulation during tumorigenesis will be critical for the next generation of cancer therapeutics.
- Type
- review
- Published
- 2016-07-28
- Cited by
- 2,543
- References
- 101
- Access
- Open access
- OpenAlex
- https://openalex.org/W2480725775
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6592458
Keywords
Mitochondrion, Biology, Bioenergetics, Cell biology, mitochondrial fusion
References
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- Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells
- An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis
- Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function
- RAS oncogenes: weaving a tumorigenic web
- Mitochondria: a historical review
- Functions and characteristics of PINK1 and Parkin in cancer.
- Mitochondria in Apoptosis: Bcl-2 family Members and Mitochondrial Dynamics
- Cellular Fatty Acid Metabolism and Cancer
- A role for the mitochondrial pyruvate carrier as a repressor of the Warburg Effect and colon cancer cell growth
- How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models.
- mTOR coordinates protein synthesis, mitochondrial activity and proliferation
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
Cited by
- Targeting SOD1 reduces experimental non–small-cell lung cancer.
- Mitonuclear interactions: evolutionary consequences over multiple biological scales
- Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade
- Estrogen potentiates reactive oxygen species (ROS) tolerance to initiate carcinogenesis and promote cancer malignant transformation
- A neuronal network of mitochondrial dynamics regulates metastasis
- Fluorescent diagnostics of epithelial neoplasms of different colon parts
- Translational control and the cancer cell response to stress.
- Multifunctional decoration of alpha-tocopheryl succinate-based NP for cancer treatment: effect of TPP and LTVSPWY peptide
- Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment
- Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance
- LKB1 Deficient Non-small Cell Lung Cancer Cells are Vulnerable to Energy Stress Induced by ATP Depletion
- Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma
- Inflammation, advancing age and nutrition
- RSC Chromatin-Remodeling Complex Is Important for Mitochondrial Function in Saccharomyces cerevisiae
- Exploitation du métabolisme mitochondrial oxydatif dans l'éradication du mélanome métastatique
- Mechanisms Underlying the Essential Role of Mitochondria in Chronological Aging of the Yeast Saccharomyces cerevisiae
- Evaluation of two mitochondrial DNA biomarkers for prostate cancer detection
- Characterization of Mild Oxidative Stress Response in Human IMR-90 Fibroblasts by Subcellular Quantitative Proteomics
- Mitochondrial dysfunction in breast cancer
- New roles for mitochondrial proteases in health, ageing and disease
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