Sirtuins and the metabolic hurdles in cancer

Keywords

Biology, Cancer cell, Bioenergetics, Cancer, Metabolic pathway

References

• Sirtuins — novel therapeutic targets to treat age-associated diseasesFrédéric Manns — 2008
• Targeting SOD1 reduces experimental non–small-cell lung cancer.Hipólito G. Navarro — 2014
• SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation.Alan W. Lau, Pengda Liu, Hiroyuki Inuzuka — 2014
• Side chain specificity of ADP-ribosylation by a sirtuinKamau Fahie, Po Hu, Stephen Swatkoski — 2009
• SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS productionEric L. Bell, Brooke M. Emerling, Stéphane J. H. Ricoult — 2011
• Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolismSarah‐Maria Fendt, Eric L. Bell, Mark A. Keibler — 2013
• Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells.Helen J. Knowles, Raju R. Raval, Adrian L. Harris — 2003
• Regulation of Sirtuin Function by Posttranslational ModificationsFranziska Flick, Bernhard Lüscher — 2012
• Regulation of Succinate Dehydrogenase Activity by SIRT3 in Mammalian MitochondriaHüseyin Çimen, Min‐Joon Han, Yongjie Yang — 2010
• Sirtuin Chemical MechanismsAnthony A. Sauve — 2010
• SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restrictionFei Wang, Margaret Nguyen, F. Xiao‐Feng Qin — 2007
• CIRCADIAN CONTROL OF THE NAD+ SALVAGE PATHWAY BY CLOCK-SIRT1Yasukazu Nakahata, Saurabh Sahar, Giuseppe Astarita — 2009
• Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial BiogenesisXingxing Kong, Rui Wang, Yuan Xue — 2010
• SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein StabilityGlenn M. Marshall, Pei Y. Liu, Samuele Gherardi — 2011
• The use of dioxygen by HIF prolyl hydroxylase (PHD1).Luke A. McNeill, Kirsty S. Hewitson, Jonathan Gleadle — 2002
• Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumoursJuliette Aury‐Landas, Gaëlle Bougeard, Hélène Castel — 2013
• Energy balance, host-related factors, and cancer progression.Stephen D. Hursting, Nathan A. Berger — 2010
• Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase ActivityLydia W.S. Finley, Wilhelm Haas, Valérie Desquiret‐Dumas — 2011
• The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.Brian J. North, Brett Marshall, Margie T. Borra — 2003
• Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicityFrank Weinberg, Robert B. Hamanaka, William W. Wheaton — 2010

Cited by

• Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progressionZhaoyong Li, Huafeng Zhang — 2015
• Targeting fatty acid metabolism in cancer and endothelial cells.Ulrike Harjes, Joanna Kalucka, Peter Carmeliet — 2016
• MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4Alexander Lang, Susanne Grether‐Beck, Madhurendra Singh — 2016
• Mitochondrial biogenesis and proteome remodeling promotes one carbon metabolism for T cell activationNoga Ron‐Harel, Daniel Santos, Jonathan M. Ghergurovich — 2016
• Mitochondria and CancerSejal Vyas, Elma Zaganjor, Marcia C. Haigis — 2016
• PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2Natalie J. German, Haejin Yoon, Rushdia Z. Yusuf — 2016
• Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-dependent Deacetylation in Response to Membrane DepolarizationWen Yang, Koji Nagasawa, Christian Münch — 2016
• Reactive oxygen species and cancer paradox: To promote or to suppress?Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy — 2017
• Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4Josefina Castex, Dominica Willmann, Toufike Kanouni — 2017
• Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription.Jianjun Deng, Ka-Yiu Edwin Kong, Weiwei Gao — 2017
• Mitochondrial Sirtuins and Molecular Mechanisms of AgingRobert A. H. van de Ven, Daniel Santos, Marcia C. Haigis — 2017
• Mitochondria and Epigenetics - Crosstalk in Homeostasis and Stress.Olli Matilainen, Pedro M. Quirós, Johan Auwerx — 2017
• Nicotinamide for skin cancer chemopreventionDiona L. Damian — 2017
• Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarctionWentao Yang, Feng Gao, Pei Zhang — 2017
• The Warburg effect in Multiple Myeloma and its microenvironmentAline Kühnel, Olga Blau, Klaus Axel Nogai — 2017
• Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus.Tingting Liu, Wentao Yang, Shuchao Pang — 2018
• SIRT3 inhibits prostate cancer metastasis through regulation of FOXO3A by suppressing Wnt/&bgr;‐catenin pathwayRong Li, Yizhou Quan, Weiliang Xia — 2018
• Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic TargetsVera Miranda‐Gonçalves, Ana Lameirinhas, Rui Henrique — 2018
• Cellular mechanisms promoting cachexia and how they are opposed by sirtuins 1.Sadhana Samant, Vinodkumar B. Pillai, Mahesh P. Gupta — 2019
• Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental ValidationElisabet Cuyàs, Sara Verdura, Laura Llorach-Parés — 2018

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