Identification of NDUFAF1 in mediating K-Ras induced mitochondrial dysfunction by a proteomic screening approach
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Summary
It is revealed that oncogenic K-Ras is able to induce significant alterations in mitochondrial protein expression, and NDUFAF1 is identified as an important molecule whose low expression contributes to mitochondrial dysfunction induced by K- Ras.
- Type
- article
- Published
- 2015-02-01
- Cited by
- 27
- References
- 35
- Access
- Open access
- OpenAlex
- https://openalex.org/W1544672207
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11036092
Keywords
Stable isotope labeling by amino acids in cell culture, Mitochondrion, Cancer, Warburg effect, Glycolysis
References
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- Mitochondria and Cancer
- Metabolic plasticity in heterogeneous pancreatic ductal adenocarcinoma.
- Targeting reactive oxygen species in development and progression of pancreatic cancer
- Metabolic Characterization of MPNST Cell Lines
- Superoxide Dismutases in Pancreatic Cancer
- Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease
- Spatial Tissue Proteomics Quantifies Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma (HCC)
- The role of compartmentalized signaling pathways in the control of mitochondrial activities in cancer cells.
- Metabolic Plasticity of Tumor Cell Mitochondria
- Micromanaging aerobic respiration and glycolysis in cancer cells
- Warburg-like effect is a hallmark of complex I assembly defects.
- PROTEINATOR: Web-UI exploring repurposing hypotheses of PROTEIN InhibiTORs based on protein interactions
- Transcriptomic analysis of prostate cancer progression
- Transcriptional Regulation of Energy Metabolism in Cancer Cells
- Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells
- Mitochondrial Respiration in KRAS and BRAF Mutated Colorectal Tumors and Polyps
- Proteomic-Based Analysis of Hypoxia- and Physioxia-Responsive Proteins and Pathways in Diffuse Large B-Cell Lymphoma
- Mitochondrial-Related Transcriptome Feature Correlates with Prognosis, Vascular Invasion, Tumor Microenvironment, and Treatment Response in Hepatocellular Carcinoma
- Supplementing Diets with Agriophyllum squarrosum Reduced Blood Lipids, Enhanced Immunity and Anti-Inflammatory Capacities, and Mediated Lipid Metabolism in Tan Lambs
- Overview of Cancer Metabolism and Signaling Transduction
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