Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus.
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Summary
This study illustrates the importance of generating different mutations at a given locus to elucidate fully the function of a particular gene during development as well as defining roles for N-myc at other stages of development.
- Type
- article
- Published
- 1993-10-01
- Cited by
- 197
- References
- 59
- OpenAlex
- https://openalex.org/W2189058568
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13448550
Keywords
Biology, Null allele, Heterozygote advantage, Allele, Locus (genetics)
References
- Mammalian lung development: interactions in primordium formation and bronchial morphogenesis.
- flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors.
- IgH enhancer‐mediated deregulation of N‐myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c‐myc expression.
- N‐myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross‐regulation with c‐myc.
- Tissue Distribution of N‐myc Expression in the Early Organogenesis Period of the Mouse Embryo
- Enhanced expression of the N-myc gene in Wilms' tumors.
- Inductive Interactions in Heart Development
- Interrelations of the proliferation and differentiation processes during cardiact myogenesis and regeneration.
- The N‐Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells.
- An amino-terminal c-myc domain required for neoplastic transformation activates transcription
- Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells
- High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination
- Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm.
- myc family oncogenes in the development of normal and neoplastic cells.
- The c-myc proto-oncogene regulates cardiac development in transgenic mice
- Gene amplification of c-myc and N-myc in small cell carcinoma of the lung.
- The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
- Biphasic effect of Max on Myc cotransformation activity and dependence on amino- and carboxy-terminal Max functions.
- A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.
- N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization
Cited by
- Molecular characterization of early cardiac development.
- Recent progress in the molecular genetics of congenital heart defects
- Versican expression is associated with chamber specification, septation, and valvulogenesis in the developing mouse heart.
- The Myc/Max/Mad network and the transcriptional control of cell behavior.
- Programmed cell death in normal fetal rat lung development.
- N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation.
- Mnt: a novel Max-interacting protein and Myc antagonist.
- Myc-mediated control of gene transcription in cancer cells
- The Mad side of the Max network: antagonizing the function of Myc and more.
- Embryonic development and pediatric oncogenesis.
- Reactivation of the cell cycle in terminally differentiated cells
- B cells and the Antibody-Dependent Immune Response in Cancer and Infection
- Epigenetic role of N-Myc in Neuroblastoma
- Mammalian NDR kinases : tumor suppressors with essential functions in embryonic development
- Role of ion and water channels for lung growth in congenital diaphragmatic hernia
- The transcription factor NF-ATc is essential for cardiac valve formation
- Growth factors in the fetal and neonatal lung.
- Functions of myc:max in the control of cell proliferation and tumorigenesis.
- Transcription factors in cardiogenesis: the combinations that unlock the mysteries of the heart.
- N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma.
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