Gene amplification of c-myc and N-myc in small cell carcinoma of the lung.
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Summary
The data suggest that gene amplification is an important step in neoplastic growth in a subset of patients with small cell carcinoma of the lung and that this genetic event occurs relatively early (before metastasis) in this subset.
- Type
- article
- Published
- 1986-07-25
- Cited by
- 273
- References
- 37
- OpenAlex
- https://openalex.org/W1966155757
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19069968
Keywords
Gene duplication, Copy-number variation, Biology, Gene dosage, Locus (genetics)
References
- Amplification, expression and rearrangement of c-myc and N-myc oncogenes in human lung cancer.
- Amplification units containing human N-myc and c-myc genes.
- Gene amplification in cultured animal cells.
- Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
- Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells.
- Transposition and amplification of oncogene-related sequences in human neuroblastomas.
- Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis
- Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
- Purification of DNA from formaldehyde fixed and paraffin embedded human tissue.
- Karyotypic characterization of established cell lines and short-term cultures of human lung cancers.
- Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
- Cellular oncogenes and multistep carcinogenesis.
- The clinical behavior of „mixed”︁ small cell/large cell bronchogenic carcinoma compared to „pure”︁ small cell subtypes
- L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer
- Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals.
- Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture
- Translocations among antibody genes in human cancer.
- Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.
- Genomic alterations involving the c-myc proto-oncogene locus during the evolution of a case of chronic granulocytic leukaemia.
- Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma.
Cited by
- Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: immunohistological assessment correlates with gene amplification.
- Oncogene expression in a medullary thyroid carcinoma
- Myc family of cellular oncogenes
- Cellular oncogenes in neoplasia.
- The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma
- Molecular biology of lung cancer.
- Amplification of DNA sequences in mammalian cells.
- Oncogene and receptor expression.
- Oncogenes and human lung cancer.
- Overexpression ofc-Ki-ras andc-fos in human pancreatic carcinomas
- Oncogenes in human solid tumors.
- What Has Cancer Taught Us about the Cell
- [The distribution of various type of oncogenes products in the tumor tissue of malignant mesothelioma].
- Molecular mechanisms of oncogenesis.
- c-Myc Function in Neoplasia
- Cyclin-D1 Modulation of Vitamin-D-Induced Gene Expression in Oral Keratinocytes
- Repression of dihydrofolate reductase synthesis during myogenesis : identification and characterization of a transcriptional regulatory mechanism
- Importance of phenotypic and molecular characterization for identification of a neuroepithelioma tumor cell line, NUB-20.
- Overexpression of dihydrodiol dehydrogenase as a prognostic marker of non-small cell lung cancer.
- Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung.
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