Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
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Summary
Since intensive glucose control with metformin appears to decrease the risk of diabetes-related endpoints in overweight diabetic patients, and is associated with less weight gain and fewer hypoglycaemic attacks than are insulin and sulphonylureas, it may be the first-line pharmacological therapy of choice in these patients.
- Type
- article
- Published
- 1998-09-12
- Cited by
- 7,934
- References
- 13
- OpenAlex
- https://openalex.org/W2188846692
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19208426
Keywords
Metformin, Overweight, Medicine, Type 2 diabetes, Diabetes mellitus
References
- United Kingdom Prospective Diabetes Study 24: A 6-Year, Randomized, Controlled Trial Comparing Sulfonylurea, Insulin, and Metformin Therapy in Patients with Newly Diagnosed Type 2 Diabetes That Could Not Be Controlled with Diet Therapy
- United Kingdom Prospective Diabetes Study 17: A 9-Year Update of a Randomized, Controlled Trial on the Effect of Improved Metabolic Control on Complications in Non-Insulin-dependent Diabetes Mellitus
- Effects of Metformin on Insulin Resistance, Risk Factors for Cardiovascular Disease, and Plasminogen Activator Inhibitor in NIDDM Subjects: A study of two ethnic groups
- Biguanides and NIDDM
- Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.
- Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
- UK Prospective Diabetes Study (UKPDS) XI: Biochemical Risk Factors in Type 2 Diabetic Patients at Diagnosis Compared with Age‐matched Normal Subjects
- U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease
- UKPDS 28: A Randomized Trial of Efficacy of Early Addition of Metformin in Sulfonylurea-Treated Type 2 Diabetes
- Metformin
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- Factors Associated With Poor Glycemic Control or Wide Glycemic Variability Among Diabetes Patients in Hawaii, 2006–2009
- Digestive hemorrhage caused by a Meckel's diverticulum in a metformin‐treated patient: is there any connection?
- Die Insulinresistenz beim polyzystischen Ovar-Syndrom
- The plasma glucose level--a continuous risk factor for vascular disease in both diabetic and non-diabetic people.
- Microalbuminuria, blood pressure and diabetic renal disease: origin and development of ideas
- Frailty Attenuates the Impact of Metformin on Reducing Mortality in Older Adults with Type 2 Diabetes
- Insulin therapy in the elderly: becoming the norm
- The effect of acute hyperglycaemia on brachial artery flow mediated dilatation in normal volunteers.
- Risks of coronary heart disease in women: current understanding and evolving concepts.
- Impact of Standalone Personal Health Record Use on Clinical Outcomes of Patients with Type 2 Diabetes: An Intervention Mixed Methods Study
- Psychological issues and treatments for people with diabetes.
- Additive glucose-lowering effects of glucagon-like peptide-1 and metformin in type 2 diabetes.
- Diabetes Screening in Canada (DIASCAN) Study: prevalence of undiagnosed diabetes and glucose intolerance in family physician offices.
- Effects of improved glycaemic control on endothelial function in patients with type 2 diabetes
- Postoperative management of the diabetic patient.
- Diabetes im Alter
- Porphyromonas gingivalis infection is associated with elevated C-reactive protein in nonobese Japanese type 2 diabetic subjects.
- Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus.
- Drugs for cardiovascular risk reduction in the diabetic patient
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