UKPDS 28: A Randomized Trial of Efficacy of Early Addition of Metformin in Sulfonylurea-Treated Type 2 Diabetes
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Summary
Early addition of metformin improved gly glucose control in patients with suboptimal glycemic control while taking maximum sulfonylurea therapy, irrespective of obesity or baseline FPG concentrations.
- Type
- article
- Published
- 1998-01-01
- Cited by
- 194
- References
- 14
- OpenAlex
- https://openalex.org/W2786617581
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8762612
Keywords
Sulfonylurea, Metformin, Medicine, Internal medicine, Glycated hemoglobin
References
- Acute Antihyperglycemic Mechanisms of Metformin in NIDDM: Evidence for Suppression of Lipid Oxidation and Hepatic Glucose Production
- Effects of Metformin on Insulin Resistance, Risk Factors for Cardiovascular Disease, and Plasminogen Activator Inhibitor in NIDDM Subjects: A study of two ethnic groups
- Sulphonylurea Failure in Type 2 Diabetes: Treatment with a Basal Insulin Supplement
- Metabolic and Hemodynamic Effects of Metformin and Glibenclamide in Normotensive NIDDM Patients
- Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells.
- Metabolic effects of metformin in non-insulin-dependent diabetes mellitus.
- UK Prospective Diabetes Study (UKPDS) XI: Biochemical Risk Factors in Type 2 Diabetic Patients at Diagnosis Compared with Age‐matched Normal Subjects
- UK Prospective Diabetes Study 6. Complications in newly diagnosed type 2 diabetic patients and their association with different clinical and biochemical risk factors.
- American Diabetes Association: clinical practice recommendations 1995.
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- Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus.
- Fixed-dose combinations improve medication compliance: a meta-analysis.
- General practitioners trained in motivational interviewing can positively affect the attitude to behaviour change in people with type 2 diabetes
- Efficacy and safety of glimepiride/metformin sustained release once daily vs. glimepiride/metformin twice daily in patients with type 2 diabetes
- Complications of Diabetes Therapy
- Population prevalence and control of cardiovascular risk factors: What electronic medical records tell us
- The effect of metformin treatment in vivo on acute and long-term energy metabolism and progesterone production in vitro by granulosa cells from women with polycystic ovary syndrome
- Analisi di costo-efficacia della terapia combinata con pioglitazone nel trattamento del diabete mellito di tipo 2 in Italia
- Management of Type 2 Diabetes Mellitus in the Elderly
- Management of Type 2 Diabetes Mellitus and Cardiovascular Risk
- Insulin therapy for type 2 diabetes: rescue, augmentation, and replacement of beta-cell function.
- Predictors and Consequences of Severe Hypoglycemia in Adults with Diabetes - A Systematic Review of the Evidence
- Rationale and options for combination therapy in the treatment of Type 2 diabetes
- A Comparison of Agents Used to Manage Type 2 Diabetes Mellitus
- Oral combination therapy with thiazolidinediones and sulfonylureas in type 2 diabetes
- The role of oral antidiabetic agents: why and when to use an early-phase insulin secretion agent in Type II diabetes mellitus
- Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions.
- The relationship between metformin therapy and the fasting plasma lactate in type 2 diabetes: The Fremantle Diabetes Study.
- Resource use among patients with diabetes, diabetic neuropathy, or diabetes with depression
- Effects of the combination of SGLT2 selective inhibitor ipragliflozin and various antidiabetic drugs in type 2 diabetic mice
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