Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.
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Summary
The ability of troglitazone to reduce insulin resistance and improves glucose tolerance in obese subjects with either impaired or normal glucose tolerance could be useful in preventing NIDDM.
- Type
- article
- Published
- 1994-11-03
- Cited by
- 987
- References
- 13
- Access
- Open access
- OpenAlex
- https://openalex.org/W2335922553
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26248233
Keywords
Troglitazone, Medicine, Insulin resistance, Internal medicine, Endocrinology
References
- Diabetes mellitus in the Pima Indians: incidence, risk factors and pathogenesis.
- Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.
- Effect of New Oral Antidiabetic Agent CS-045 on Glucose Tolerance and Insulin Secretion in Patients with NIDDM
- Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects
- In vitro studies on the action of CS-045, a new antidiabetic agent.
- Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects.
- Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.
- Insulin Responses in Equivocal and Definite Diabetes, with Special Reference to Subjects Who Had Mild Glucose Intolerance but Later Developed Definite Diabetes
- Insulin Insensitivity in Offspring of Parents with Type 2 Diabetes Mellitus
- INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT *
- Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.
- Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus.
- Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians.
- Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution
- Characterization of new oral antidiabetic agent CS-045. Studies in KK and ob/ob mice and Zucker fatty rats
- Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates
Cited by
- TRIPOD (TRoglitazone In the Prevention Of Diabetes): a randomized, placebo-controlled trial of troglitazone in women with prior gestational diabetes mellitus.
- Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus: an hypothesis.
- Thiazolidinediones: a new class of antidiabetic drugs
- Cardiac hypertrophy in diabetes patients with and without hypertension: effects of troglitazone, a novel antidiabetic drug, on diastolic function.
- Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats.
- Troglitazone enhances glycolysis and improves intracellular glucose metabolism in rat mesangial cells.
- Insulin sensitizer, troglitazone, directly inhibits aromatase activity in human ovarian granulosa cells.
- Significance of Pro12Ala mutation in peroxisome proliferator-activated receptor-gamma2 in Korean diabetic and obese subjects.
- Troglitazone Downregulates Δ-6 Desaturase Gene Expression in Human Skeletal Muscle Cell Cultures
- Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.
- Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus.
- Pioglitazone Improves Insulin Sensitivity Among Nondiabetic Patients With a Recent Transient Ischemic Attack or Ischemic Stroke
- Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
- Thiazolidinediones, insulin resistance and obesity: finding a balance
- Treatment of Spontaneously Hypertensive Rats With Rosiglitazone and/or Enalapril Restores Balance Between Vasodilator and Vasoconstrictor Actions of Insulin With Simultaneous Improvement in Hypertension and Insulin Resistance
- American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus.
- Hypoglycemic pharmacological treatment of type 2 diabetes: targeting the endothelium.
- Peroxisome proliferator-activated receptor gamma ligand-mediated apoptosis of hepatocellular carcinoma cells depends upon modulation of PI3Kinase pathway independent of Akt
- Peroxisome proliferators-activated receptor γ2 Pro12Ala variant is associated with body mass index in non-alcoholic fatty liver disease patients
- Diabetes Screening and Surveillance Programmes
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