Frailty Attenuates the Impact of Metformin on Reducing Mortality in Older Adults with Type 2 Diabetes
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Summary
It is suggested that metformin could potentially promote longevity via preventing frailty in older adults with type 2 diabetes.
- Type
- article
- Published
- 2014-05-28
- Cited by
- 63
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W10181678
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23018779
Keywords
Metformin, Medicine, Sulfonylurea, Hazard ratio, Type 2 diabetes
References
- The metabolic syndrome: the crossroads between rheumatoid arthritis and cardiovascular risk.
- Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
- Plasma Hypertonicity: Another Marker of Frailty?
- Racial differences in mortality among men hospitalized in the Veterans Affairs health care system.
- Racial differences in diabetic nephropathy, cardiovascular disease, and mortality in a national population of veterans.
- Calorie restriction mimetics: an emerging research field
- AMPK - a nutrient and energy sensor that maintains energy homeostasis
- Screening for Frailty: Criteria and Predictors of Outcomes
- Effect of Metformin-Containing Antidiabetic Regimens on All-cause Mortality in Veterans With Type 2 Diabetes Mellitus
- Sulphonylureas and risk of cardiovascular disease: systematic review and meta‐analysis
- Effect of metformin on cardiovascular events and mortality: a meta‐analysis of randomized clinical trials
- Cardiovascular Effects of Diabetes Drugs: Emerging From the Dark Ages
- Screening Candidate Longevity Therapeutics Using Gene-Expression Arrays
- Inflammatory Exposure and Historical Changes in Human Life-Spans
- Comparative effectiveness of sulfonylurea and metformin monotherapy on risk of cardiovascular events in type 2 diabetes mellitus
- Initiation of insulin among veterans with type 2 diabetes and sustained elevation of A1c.
- Frailty Transitions in the San Antonio Longitudinal Study of Aging
- Individualising Therapy for Older Adults with Diabetes Mellitus
- Influence of Frailty‐Related Diagnoses, High‐Risk Prescribing in Elderly Adults, and Primary Care Use on Readmissions in Fewer than 30 Days for Veterans Aged 65 and Older
- Combination therapy with sulfonylureas and metformin and the prevention of death in type 2 diabetes: a nested case‐control study
Cited by
- Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic
- Social vulnerability and survival across levels of frailty in the Honolulu-Asia Aging Study.
- Successful Aging: Advancing the Science of Physical Independence in Older Adults
- Metformin: A Hopeful Promise in Aging Research.
- The effect of frailty should be considered in the management plan of older people with Type 2 diabetes
- The emergence of frailty may burn out type 2 diabetes‐a hypothesis
- Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes
- Energetic Interventions for healthspan and resiliency with aging
- A story of metformin‐butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug?
- Differential effects of metformin on age related comorbidities in older men with type 2 diabetes
- Frailty and sarcopenia - newly emerging and high impact complications of diabetes.
- Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.
- Blood Glucose Management of Type 2 Diabetes in the Older People
- Diabetes Treatment in the Elderly: Incorporating Geriatrics, Technology, and Functional Medicine
- Metformin as a geroprotector: experimental and clinical evidence
- The Burden of Frailty Among U.S. Veterans and Its Association With Mortality, 2002-2012.
- Associations between multimorbidity, all-cause mortality and glycaemia in people with type 2 diabetes: A systematic review
- Senolytics and senostatics as adjuvant tumour therapy
- Geroprotectors: A role in the treatment of frailty.
- Review of Interventions for the Frailty Syndrome and the Role of Metformin as a Potential Pharmacologic Agent for Frailty Prevention
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