A family of human receptors structurally related to Drosophila Toll.
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Summary
This work reports the molecular cloning of a class of putative human receptors with a protein architecture that is similar to Drosophila Toll in both intra- and extracellular segments and indicates markedly different patterns of expression for the human TLRs.
- Type
- article
- Published
- 1998-01-20
- Cited by
- 1,982
- References
- 54
- Access
- Open access
- OpenAlex
- https://openalex.org/W2171260427
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8947970
Keywords
Biology, Innate immune system, Receptor, Cell biology, Genetics
References
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- Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats.
- Structural conservation in the CheY superfamily.
- T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family (*)
- Dorsal or ventral: similarities in fate maps and gastrulation patterns in annelids, arthropods and chordates.
- Immune reactions in Drosophila and other insects: a model for innate immunity.
- The origin of pattern and polarity in the Drosophila embryo.
- A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled(*)
- A common plan for dorsoventral patterning in Bilateria
- Issues in searching molecular sequence databases
- Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila.
- Dimerization of cell surface receptors in signal transduction
- The vertebrate organizer: structure and molecules.
Cited by
- Two receptor theory in innate immune activation: studies on the receptors for bacillus Culmet Guillen-cell wall skeleton.
- Genetics of Multiple Sclerosis
- Toll-like receptor 3 activation promotes desensitization of histamine response in human gingival fibroblasts: Poly (I:C) induces histamine receptor desensitization in human gingival fibroblasts.
- Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway
- Innate immunity: Lipoproteins take their Toll on the host
- Toll-Like Receptors Confer Responsiveness to Lipopolysaccharide from Porphyromonas gingivalis in Human Gingival Fibroblasts
- Involvement of a membrane-associated serine/threonine kinase complex in cellular binding of visna virus.
- Toll‐like receptors: molecular mechanisms of the mammalian immune response
- Cinderella goes to the ball
- Hormonal genomics.
- Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway.
- Lipopolysaccharide Stimulates p38-dependent Induction of Antiviral Genes in Neutrophils Independently of Paracrine Factors*
- CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.
- The Urokinase Receptor Can Be Induced by Borrelia burgdorferi through Receptors of the Innate Immune System
- Structure-Activity Relationship of Synthetic Toll-like Receptor 4 Agonists*
- Toll‐like receptor 9 binds single‐stranded CpG‐DNA in a sequence‐ and pH‐dependent manner
- The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection.
- Identification and Functional Characterization of Chicken Toll-Like Receptor 5 Reveals a Fundamental Role in the Biology of Infection with Salmonella enterica Serovar Typhimurium
- Adipocytes, myofibers, and cytokine biology: new horizons in the regulation of growth and body composition.
- Spezies-spezifische und Zelltyp-spezifische Regulation von Toll-like Rezeptoren
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