Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.
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Summary
Reversion to drug sensitivity was associated with loss of gene amplification and a marked decrease in mRNA expression, and the mRNA encodes a member of the ATP-binding cassette transmembrane transporter superfamily.
- Type
- article
- Published
- 1992-12-04
- Cited by
- 3,158
- References
- 41
- OpenAlex
- https://openalex.org/W2168070336
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24186648
Keywords
Complementary DNA, Biology, ABCC1, Gene, Molecular biology
References
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Cited by
- Generation and characterisation of antibodies specific for the multidrug resistance-associated protein, MRP
- Classification of membrane transporters.
- Basic Mechanisms of Antibiotic Resistance: Molecular Properties of Multidrug Transporters
- Biology of Membrane Transport Proteins
- Localisation of the multidrug resistance-associated protein, MRP, in resistant large-cell lung tumour cells.
- P-glycoprotein homologues.
- Human cell lines as models for multidrug resistance in solid tumours
- Mechanisms of MRP over‐expression in four human lung‐cancer cell lines and analysis of the MRP amplicon
- Glutathione and related enzymes in multidrug resistance.
- Expression of multidrug‐resistance‐associated protein (MRP) and chemosensitivity in human gastric cancer
- Identification of the multidrug-resistance protein (MRP) as the glutathione-S-conjugate export pump of erythrocytes.
- A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium.
- Resistance of mammalian tumor cells to inhibitors of DNA topoisomerase II.
- Active efflux of the free acid form of the fluorescent dye 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein in multidrug-resistance-protein-overexpressing murine and human leukemia cells.
- Response to ICRF-159 in cell lines resistant to cleavable complex-forming topoisomerase II inhibitors.
- Aging and cancer: issues of basic and clinical science.
- Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA.
- A novel bioassay for P-glycoprotein functionality using cytochalasin D.
- Cytochrome P450 3A and ABC-transport proteins in horse
- Vaults Are Up-regulated in Multidrug-resistant Cancer Cell Lines*
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